3-Methoxy-5-phenylpyridine

Base Information

• Chemical Name: 3-Methoxy-5-phenylpyridine
• CAS No.: 53698-52-5
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Hs Code.: 2933399090
• Mol file: 53698-52-5.mol

Synonyms:3-Methoxy-5-phenylpyridine

Chemical Property of 3-Methoxy-5-phenylpyridine

Chemical Property:

• PSA: 22.12000
• LogP: 2.75720
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

3-methoxy-5-phenylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methoxy-5-phenylpyridine

There total 6 articles about 3-Methoxy-5-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-iodo-5-methoxy-pyridine (873302-36-4) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 3-methoxy-5-phenylpyridine (53698-52-5)

Guidance literature:

With N-methyl-o-aminobenzyl alcohol; potassium tert-butylate; at 100 ℃; for 24h; Sealed tube;

DOI:10.1039/d0ra01845g

Reference yield: 76.0%

5-methoxy-3-pyridinylboronic acid (850991-69-4) + bromobenzene (108-86-1,52753-63-6) → 3-methoxy-5-phenylpyridine (53698-52-5)

Guidance literature:

With sodium carbonate; In water; N,N-dimethyl-formamide; at 90 ℃; for 1h;

DOI:10.3762/bjoc.7.41

Reference yield: 72.0%

5-methoxy-3-pyridinylboronic acid (850991-69-4) + iodobenzene (591-50-4) → 3-methoxy-5-phenylpyridine (53698-52-5)

Guidance literature:

With sodium carbonate; In water; N,N-dimethyl-formamide; at 90 ℃; for 1h;

DOI:10.3762/bjoc.7.41

upstream raw materials:

3-bromo-5-methoxypyridine

phenylboronic acid

5-methoxy-3-pyridinylboronic acid

bromobenzene

Downstream raw materials:

5-phenylpyridin-3-ol

Refernces

• 1、 Wang, Xiajun,He, Yongqin,Ren, Mengdan,Liu, Shengkang,Liu, He,Huang, Guosheng. "Pd-Catalyzed Ligand-Free Synthesis of Arylated Heteroaromatics by Coupling of N-Heteroaromatic Bromides with Iodobenzene Diacetate, Iodosobenzene, or Diphenyliodonium Salts". . p. 7958 - 7962. Retrieved 2016/09/09.
• 2、 Tony, Kurissery A.,Chittimalla, Santhosh Kumar,Abraham Rajkumar,Chakrabarti, Anjan. "Regioselective synthesis of 2,3-dihydrospiro[1,4]dioxino[2,3-b]pyridine derivatives". scheme or table. p. 4350 - 4353. Retrieved 2010/09/12.