3-Hydroxy-5-phenylpyridine

Base Information

• Chemical Name: 3-Hydroxy-5-phenylpyridine
• CAS No.: 31676-55-8
• Molecular Formula: C11H9NO
• Molecular Weight: 171.199
• Hs Code.: 2933399090
• European Community (EC) Number: 862-306-8
• DSSTox Substance ID: DTXSID20376557
• Nikkaji Number: J3.434.052H
• Wikidata: Q82165451
• Mol file: 31676-55-8.mol

Synonyms:5-phenylpyridin-3-ol;3-HYDROXY-5-PHENYLPYRIDINE;31676-55-8;3-Pyridinol, 5-phenyl-;5-Phenylpyridine-3-ol;SCHEMBL1026676;DTXSID20376557;MFCD04114220;AKOS006292660;CS-0195675;FT-0759189;E89742;EN300-216627;A1-34111;Z1198164227

Chemical Property of 3-Hydroxy-5-phenylpyridine

Chemical Property:

• Vapor Pressure: 5.06E-08mmHg at 25°C
• Refractive Index: 1.611
• Boiling Point: 430.7 °C at 760 mmHg
• Flash Point: 214.3 °C
• PSA: 33.12000
• Density: 1.169 g/cm³
• LogP: 2.45420
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 171.068413911
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

98%Min ^*data from raw suppliers

5-phenylpyridin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=CN=C2)O

Technology Process of 3-Hydroxy-5-phenylpyridine

There total 4 articles about 3-Hydroxy-5-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-bromopyridine-3-ol (74115-13-2) + phenylmagnesium bromide (100-58-3) → 5-phenylpyridin-3-ol (31676-55-8)

Guidance literature:

phenylmagnesium bromide; With titanium(IV) tetraethanolate; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

5-bromopyridine-3-ol; With tributylphosphine; cobalt(II) chloride; In tetrahydrofuran; at 20 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ol402599f

Reference yield: 37.0%

→ 5-phenylpyridin-3-ol (31676-55-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; for 40h; Reflux;

Reference yield:

3-methoxy-5-phenylpyridine (53698-52-5) → 5-phenylpyridin-3-ol (31676-55-8)

Guidance literature:

3-methoxy-5-phenylpyridine; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 18.33h;

With water; sodium hydrogencarbonate; In dichloromethane; pH=8;

upstream raw materials:

3-methoxy-5-phenylpyridine

5-bromopyridine-3-ol

phenylmagnesium bromide

water