(1S)-Methyl-2-furanylMethylaMine

Base Information

• Chemical Name: (1S)-Methyl-2-furanylMethylaMine
• CAS No.: 27948-38-5
• Molecular Formula: C6H9NO
• Molecular Weight: 111.144
• Mol file: 27948-38-5.mol

Synonyms:(1S)-Methyl-2-furanylMethylaMine;(1S)-1-(FURAN-2-YL)ETHAN-1-AMINE;(S)-1-(furan-2-yl)ethanamine

Chemical Property of (1S)-Methyl-2-furanylMethylaMine

Chemical Property:

• Boiling Point: 80-95 °C(Press: 11 Torr)
• PKA: 9.58±0.29(Predicted)
• PSA: 39.16000
• Density: 1.015±0.06 g/cm3(Predicted)
• LogP: 1.99960

Purity/Quality:

98% ^*data from raw suppliers

(S)-1-(Furan-2-yl)ethanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S)-Methyl-2-furanylMethylaMine

There total 3 articles about (1S)-Methyl-2-furanylMethylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(furan-2-yl)ethanamine (22095-34-7) + ethyl 4-chloro-3-hydroxybutanoate (86728-85-0,87068-18-6,90866-33-4,10488-69-4) → ethyl (L)-4-chloro-3-hydroxybutyrate (10488-69-4,86728-85-0,87068-18-6,90866-33-4) + (1S)-1-(furan-2-yl)ethanamine (27948-38-5) + (3S,1'R)-4-chloro-N-<1-(2-furyl)ethyl>3-hydroxybutanamide (222311-41-3) + (3R,1'R)-4-chloro-N-<1-(2-furyl)ethyl>3-hydroxybutanamide

Guidance literature:

With Candida antarctica lipase; 4 Angstroems MS; In 1,4-dioxane; at 30 ℃; for 24h; Product distribution;

DOI:10.1021/jo981630a

Reference yield:

1-(2-furyl)-1-ethanone (1192-62-7,80145-44-4) → (1S)-1-(furan-2-yl)ethanamine (27948-38-5) + (R)-1-(furan-2-yl)ethanamine (132523-44-5)

Guidance literature:

With (R)-1-phenyl-ethyl-amine; In aq. phosphate buffer; at 30 ℃; for 24h; pH=7.5; Reagent/catalyst; Overall yield = 54 %; Enzymatic reaction;

DOI:10.1039/c6gc02241c

Reference yield:

(1R,2R,5R)-3-[(E)-1-Furan-2-yl-ethylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol → (1S)-1-(furan-2-yl)ethanamine (27948-38-5) + (R)-1-(furan-2-yl)ethanamine (132523-44-5)

Guidance literature:

With hydroxylamine acetate; In ethanol; for 24h; Yield given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1080/00397919308011135

upstream raw materials:

1-(furan-2-yl)ethanamine

ethyl 4-chloro-3-hydroxybutanoate

1-(2-furyl)-1-ethanone

Downstream raw materials:

(S)-N-[1-(furan-2-yl)ethyl]benzamide

L-alanin

NMS-P₅₁₅

(1R)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide

Refernces

• 1、 Dunbabin, Alice,Subrizi, Fabiana,Ward, John M.,Sheppard, Tom D.,Hailes, Helen C.. "Furfurylamines from biomass: Transaminase catalysed upgrading of furfurals". . p. 397 - 404. Retrieved 2017/01/29.
• 2、 Shikui,Aiqiao,Lanjun,Yaozhong. "Asymmetric synthesis. XVIII. Stereocontrolled synthesis of α-substituted-2-furfurylamines via chiral intermediates". . p. 2485 - 2488. Retrieved 2007/10/02.