tert-butyl 4-(chloromethyl)phenylcarbamate

Base Information

• Chemical Name: tert-butyl 4-(chloromethyl)phenylcarbamate
• CAS No.: 916578-53-5
• Molecular Formula: C12H16ClNO2
• Molecular Weight: 241.718
• Mol file: 916578-53-5.mol

Synonyms:tert-butyl 4-(chloromethyl)phenylcarbamate

Chemical Property of tert-butyl 4-(chloromethyl)phenylcarbamate

Chemical Property:

• PSA: 38.33000
• LogP: 3.84540

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(4-(chloromethyl)phenyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(chloromethyl)phenylcarbamate

There total 4 articles about tert-butyl 4-(chloromethyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

tert-butyl N-[4-(hydroxymethyl)phenyl]carbamate (144072-29-7) → tert-butyl (4-(chloromethyl)phenyl)carbamate (916578-53-5)

Guidance literature:

With pyridine; thionyl chloride; In dichloromethane; for 0.5h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4-aminobenzenemethanol (623-04-1) → tert-butyl (4-(chloromethyl)phenyl)carbamate (916578-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane; water / 1.5 h / 0 - 20 °C

2: pyridine; thionyl chloride / dichloromethane / 0.5 h

With pyridine; sodium hydroxide; thionyl chloride; In 1,4-dioxane; dichloromethane; water;

Reference yield:

4-(N-tert-butoxycarbonyl)aminobenzoic acid (66493-39-8) → tert-butyl (4-(chloromethyl)phenyl)carbamate (916578-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: isobutyl chloroformate / dichloromethane / 0.25 h

2: hydrogenchloride / water / 1 h

With hydrogenchloride; isobutyl chloroformate; In dichloromethane; water;

DOI:10.1016/j.bmcl.2011.06.027

upstream raw materials:

tert-butyl N-[4-(hydroxymethyl)phenyl]carbamate

4-(N-tert-butoxycarbonyl)aminobenzoic acid

di-tert-butyl dicarbonate

4-aminobenzenemethanol

Downstream raw materials:

(4-isothiocyanatomethyl-phenyl)-carbamic acid tert-butyl ester

C₁₇H₂₃N₃O₄S

C₁₈H₂₃N₃O₄S

C₁₇H₂₂ClN₃O₄S