rac-tert-butyl {1-[({6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

Base Information

Chemical Name:rac-tert-butyl {1-[({6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate
CAS No.:1609348-37-9
Molecular Formula:C₂₆H₃₁ClF₂N₄O₄
Molecular Weight:537.006
Hs Code.:

Synonyms:rac-tert-butyl {1-[({6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

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Chemical Property of rac-tert-butyl {1-[({6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

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Technology Process of rac-tert-butyl {1-[({6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

There total 6 articles about rac-tert-butyl {1-[({6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 871235-24-4,400652-50-8
2-methyl-2-propanyl (1-amino-3-methyl-2-butanyl)carbamate

: 1609082-31-6
6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid

: 1609348-37-9
rac-tert-butyl {1-[({6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

Guidance literature:: 6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid; With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

2-methyl-2-propanyl (1-amino-3-methyl-2-butanyl)carbamate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 74115-12-1
5-chloropyridin-3-ol

: 1609348-37-9
rac-tert-butyl {1-[({6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: hydrogenchloride; iron / ethanol; water / 0.5 h / Reflux

4.1: ethanol / Molecular sieve; Reflux

5.1: water; lithium hydroxide / methanol; tetrahydrofuran / 20 °C

6.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

6.2: 20 °C

With 4-methyl-morpholine; hydrogenchloride; sulfuric acid; water; nitric acid; iron; caesium carbonate; HATU; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 936247-35-7
5-chloro-2-nitropyridin-3-ol

: 1609348-37-9
rac-tert-butyl {1-[({6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: hydrogenchloride; iron / ethanol; water / 0.5 h / Reflux

3.1: ethanol / Molecular sieve; Reflux

4.1: water; lithium hydroxide / methanol; tetrahydrofuran / 20 °C

5.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

5.2: 20 °C

With 4-methyl-morpholine; hydrogenchloride; water; iron; caesium carbonate; HATU; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;