Benzene, [[(2,2-diMethyl-3-butyn-1-yl)oxy]Methyl]-

Base Information

• Chemical Name: Benzene, [[(2,2-diMethyl-3-butyn-1-yl)oxy]Methyl]-
• CAS No.: 1092536-54-3
• Molecular Formula: C13H16O
• Molecular Weight: 188.269
• Hs Code.: 2909309090
• Mol file: 1092536-54-3.mol

Synonyms:Benzene, [[(2,2-diMethyl-3-butyn-1-yl)oxy]Methyl]-;4-Benzyloxy-3,3-diMethylbut-1-yne;(((2,2-diMethylbut-3-yn-1-yl)oxy)Methyl)benzene

Chemical Property of Benzene, [[(2,2-diMethyl-3-butyn-1-yl)oxy]Methyl]-

Chemical Property:

• Boiling Point: 255.6±23.0 °C(Predicted)
• PSA: 9.23000
• Density: 0.965±0.06 g/cm3(Predicted)
• LogP: 2.86260

Purity/Quality:

99%, ^*data from raw suppliers

4-Benzyloxy-3,3-dimethylbut-1-yne ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, [[(2,2-diMethyl-3-butyn-1-yl)oxy]Methyl]-

There total 11 articles about Benzene, [[(2,2-diMethyl-3-butyn-1-yl)oxy]Methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

[{(4,4-dibromo-2,2-dimethylbut-3-en-1-yl)oxy}methyl]benzene (1402615-92-2) → [{(2,2-dimethylbut-3-yn-1-yl)oxy}methyl]benzene (1092536-54-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo301817w DOI:10.1021/jo301817w

Reference yield: 81.0%

3-benzyloxypivalic aldehyde (38216-93-2) + dimethyl (1-diazo-2-oxo-2-phenylethyl)phosphonate (60190-80-9) → [{(2,2-dimethylbut-3-yn-1-yl)oxy}methyl]benzene (1092536-54-3)

Guidance literature:

3-benzyloxypivalic aldehyde; dimethyl (1-diazo-2-oxo-2-phenylethyl)phosphonate; With potassium carbonate; In methanol; at 0 - 20 ℃; Inert atmosphere;

With sodium hydroxide; In methanol; for 2h; Reflux; Inert atmosphere; Large scale reaction;

DOI:10.1016/j.tetlet.2008.09.114

Reference yield: 69.0%

(4-(benzyloxy)-3,3-dimethylbut-1-ynyl)trimethylsilane (1294504-65-6) → [{(2,2-dimethylbut-3-yn-1-yl)oxy}methyl]benzene (1092536-54-3)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 16h;

upstream raw materials:

3-benzyloxypivalic aldehyde

dimethyl (1-diazo-2-oxo-2-phenylethyl)phosphonate

(3-chloro-3-methylbut-1-yn-1-yl)trimethylsilane

(4-(benzyloxy)-3,3-dimethylbut-1-ynyl)trimethylsilane

Downstream raw materials:

1,10-bis(benzyloxy)-7-(4-methoxybenzyloxy)-2,2-dimethyldec-3-yn-5-one

(R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide

(2R)-1-{5-amino-2-[1-(benzyloxy)-2-methylpropan-2-yl]-6-fluoro-1H-indol-1-yl}-3-(benzyloxy)propan-2-ol

N-{1-[(2R)-3-(benzyloxy)-2-hydroxypropyl]-2-[1-(benzyloxy)-2-methylpropan-2-yl]-6-fluoro-1H-indol-5-yl}-1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carboxamide

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