tert-butyl N-[(3R,4R)-4-fluoropiperidin-3-yl]carbamate

Base Information

Chemical Name:tert-butyl N-[(3R,4R)-4-fluoropiperidin-3-yl]carbamate
CAS No.:1052713-47-9
Molecular Formula:C10H19FN2O2
Molecular Weight:218.271
Hs Code.:
Mol file:1052713-47-9.mol

Synonyms:tert-butyl N-[(3R,4R)-4-fluoropiperidin-3-yl]carbamate;tert-Butyl ((3R,4R)-4-fluoropiperidin-3-yl)carbamate

Suppliers and Price of tert-butyl N-[(3R,4R)-4-fluoropiperidin-3-yl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Synthonix
(3R,4R)-3-(Boc-amino)-4-fluoropiperidine 95+%
500mg
$ 420.00

Synthonix
(3R,4R)-3-(Boc-amino)-4-fluoropiperidine 95+%
250mg
$ 250.00

Synthonix
(3R,4R)-3-(Boc-amino)-4-fluoropiperidine 95+%
100mg
$ 160.00

Synthonix
(3R,4R)-3-(Boc-amino)-4-fluoropiperidine 95+%
1g
$ 700.00

Synthonix
(3R,4R)-3-(Boc-amino)-4-fluoropiperidine 95+%
5g
$ 2110.00

J&W Pharmlab
(3R,4R)-(4-Fluoro-piperidin-3-yl)-carbamicacidtert-butylester 97%
5g
$ 1690.00

J&W Pharmlab
(3R,4R)-(4-Fluoro-piperidin-3-yl)-carbamicacidtert-butylester 97%
1g
$ 450.00

Crysdot
tert-Butyl((3R,4R)-4-fluoropiperidin-3-yl)carbamate 95+%
100mg
$ 630.00

Crysdot
tert-Butyl((3R,4R)-4-fluoropiperidin-3-yl)carbamate 95+%
250mg
$ 1008.00

Crysdot
tert-Butyl((3R,4R)-4-fluoropiperidin-3-yl)carbamate 95+%
1g
$ 2520.00

Total 13 raw suppliers

Chemical Property of tert-butyl N-[(3R,4R)-4-fluoropiperidin-3-yl]carbamate

Chemical Property:

Boiling Point:313.3±42.0 °C(Predicted)
PKA:11.22±0.40(Predicted)
PSA：50.36000
Density:1.08±0.1 g/cm3(Predicted)
LogP:1.93080

Purity/Quality:

97% ^*data from raw suppliers

(3R,4R)-3-(Boc-amino)-4-fluoropiperidine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl N-[(3R,4R)-4-fluoropiperidin-3-yl]carbamate

There total 5 articles about tert-butyl N-[(3R,4R)-4-fluoropiperidin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1052713-38-8
benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate

: 1052713-47-9,1052713-46-8,1363382-99-3,1523530-35-9
tert-butyl n-[(3R,4R)-4-fluoropiperidin-3-yl]carbamate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; for 72h;

Reference yield: 93.0%

: 1052713-47-9,1052713-46-8,1363382-99-3,1523530-35-9
tert-butyl n-[(3R,4R)-4-fluoropiperidin-3-yl]carbamate

Guidance literature:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1052713-47-9,1052713-46-8,1363382-99-3,1523530-35-9
tert-butyl n-[(3R,4R)-4-fluoropiperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium hydroxide; water / ethanol / 5 h / 70 °C

1.2: 2 h / 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane; water / 15 h / -78 - 20 °C

3.1: Chiralpak AS / isopropyl alcohol; n-heptane / Resolution of racemate

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 72 h

With ammonium hydroxide; diethylamino-sulfur trifluoride; water; hydrogen; palladium 10% on activated carbon; In ethanol; n-heptane; dichloromethane; water; ethyl acetate; isopropyl alcohol;