benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate

Base Information

• Chemical Name: benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate
• CAS No.: 1052713-38-8
• Molecular Formula: C₁₈H₂₅FN₂O₄
• Molecular Weight: 352.406

Synonyms:benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate

Chemical Property of benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

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MSDS Files:

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Technology Process of benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate

There total 7 articles about benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl n-[(3R,4R)-4-fluoropiperidin-3-yl]carbamate (1052713-47-9,1052713-46-8,1363382-99-3,1523530-35-9) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate (1052713-38-8)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water; at 0 - 15 ℃; for 16h;

Reference yield:

(3R,4R)-benzyl 3-(tert-butoxycarbonylamino)-4-fluoropiperidine-1-carboxylate (1214242-81-5) → benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate (1052713-38-8) + (3S,4S)-benzyl 3-(tert-butoxycarbonylamino)-4-fluoropiperidine-1-carboxylate (1052713-39-9)

Guidance literature:

With CHIRALPAK AS; In n-heptane; isopropyl alcohol; Resolution of racemate;

Reference yield:

benzyl 3-((tert-butoxycarbonyl)amino)-4-fluoropiperidine-1-carboxylate → benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-fluoropiperidine-1-carboxylate (1052713-38-8) + (3S,4S)-benzyl 3-(tert-butoxycarbonylamino)-4-fluoropiperidine-1-carboxylate (1052713-39-9)

Guidance literature:

With Chiralpak AS; In n-heptane; isopropyl alcohol; Resolution of racemate;

upstream raw materials:

(3R,4R)-benzyl 3-(tert-butoxycarbonylamino)-4-fluoropiperidine-1-carboxylate

di-tert-butyl dicarbonate

3,4-epoxy-piperidine-1-carboxylic acid benzyl ester

(trans)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate

Downstream raw materials:

tert-butyl n-[(3R,4R)-4-fluoropiperidin-3-yl]carbamate

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