Atropine sulfate

Base Information

Chemical Name:Atropine sulfate
CAS No.:83454-31-3
Molecular Formula:C₁₇H₂₃NO₃
Molecular Weight:289.375
Hs Code.:
European Community (EC) Number:202-933-0
DSSTox Substance ID:DTXSID00858967
Nikkaji Number:J721.767F,J23.935F
Wikipedia:Hyoscyamine
Wikidata:Q27181620
NCI Thesaurus Code:C2744,C29104,C74575
RXCUI:1225,153970,153971
Pharos Ligand ID:X6TMUUXQUXLF
Metabolomics Workbench ID:143569
ChEMBL ID:CHEMBL9751

Synonyms:Anaspaz;Atropine Sulfate, 3(S)-endo-Isomer;Atropine, 3(S)-endo-Isomer;Cytospaz;Hyoscyamine;Hyoscyamine Hydrobromide;Hyoscyamine Hydrochloride;Hyoscyamine Sulfate;Hyoscyamine Sulfate Anhydrous

Suppliers and Price of Atropine sulfate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Atropine sulfate

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:289.16779360
Heavy Atom Count:21
Complexity:353

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Drug Classes:Gastrointestinal Agents
Canonical SMILES:CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
Recent ClinicalTrials:Low-dose Atropine Eye Drops to Reduce Progression of Myopia in Children in the United Kingdom
Recent EU Clinical Trials:Investigator led, double-masked, multicenter, randomized clinical trial for the comparison of Atropine 0.5% versus Atropine 0.05% eye drops for the prevention of myopia progression in Dutch children.

Technology Process of Atropine sulfate

There total 11 articles about Atropine sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101-31-5,13269-35-7,16175-85-2,83454-31-3,98302-33-1,131432-21-8,51-55-8
Hyoscyanin

Guidance literature:: Erwaermen von Phenylacetyltropein u. Paraformaldehyd mit methanol. Triton-B-methoxydlsg. in CH3-SO-CH3 auf dem W.-bad;

Reference yield:

: 529-64-6,28845-94-5
Tropic acid

: 51-55-8,13269-35-7,16175-85-2,83454-31-3,98302-33-1,131432-21-8,101-31-5
hyoscyamine

Guidance literature:: Multi-step reaction with 3 steps

2: 2 h / Heating

3: 1.) SOCl₂, 3.) conc. HCl / 1.) 60 deg C, 2.5 h, 2.) 80 deg C, 2 h, 3.) H₂O, room temperature, 24 h

With hydrogenchloride; thionyl chloride;
DOI:10.1016/S0223-5234(97)83285-0

Reference yield:

: 16202-15-6,28845-94-5
(S)-tropic acid

: 51-55-8,13269-35-7,16175-85-2,83454-31-3,98302-33-1,131432-21-8,101-31-5
hyoscyamine

Guidance literature:: Multi-step reaction with 2 steps

1: 2 h / Heating

2: 1.) SOCl₂, 3.) conc. HCl / 1.) 60 deg C, 2.5 h, 2.) 80 deg C, 2 h, 3.) H₂O, room temperature, 24 h

With hydrogenchloride; thionyl chloride;
DOI:10.1016/S0223-5234(97)83285-0