8-(cyanomethyl)-8-azabicyclo[3.2.1]oct-3-yl-2-phenyl-3-hydroxypropanoate

Base Information

• Chemical Name: 8-(cyanomethyl)-8-azabicyclo[3.2.1]oct-3-yl-2-phenyl-3-hydroxypropanoate
• CAS No.: 131444-46-7
• Molecular Formula: C₁₈H₂₂N₂O₃
• Molecular Weight: 314.384
• Mol file: 131444-46-7.mol

Synonyms:8-(cyanomethyl)-8-azabicyclo[3.2.1]oct-3-yl-2-phenyl-3-hydroxypropanoate

Chemical Property of 8-(cyanomethyl)-8-azabicyclo[3.2.1]oct-3-yl-2-phenyl-3-hydroxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(cyanomethyl)-8-azabicyclo[3.2.1]oct-3-yl-2-phenyl-3-hydroxypropanoate

There total 2 articles about 8-(cyanomethyl)-8-azabicyclo[3.2.1]oct-3-yl-2-phenyl-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

trimethylsilyl cyanide (7677-24-9) + atropine (83454-31-3,784090-27-3,791013-25-7) → 8-(cyanomethyl)-8-azabicyclo[3.2.1]oct-3-yl-2-phenyl-3-hydroxypropanoate (131444-46-7)

Guidance literature:

With oxygen; N,N'-dimethyl-2,7-diazapyrene bis(tetrafluoroborate); In acetonitrile; at 20 ℃; for 2.3h; Irradiation;

DOI:10.1016/S0040-4039(00)97719-0

Reference yield: 72.5%

potassium cyanide + atropine (111295-08-0,737703-66-1,693209-51-7) → 8-(cyanomethyl)-8-azabicyclo[3.2.1]oct-3-yl-2-phenyl-3-hydroxypropanoate (131444-46-7)

Guidance literature:

With oxygen; rose bengal; In water; acetonitrile; for 0.05h; Irradiation; Inert atmosphere;

DOI:10.1002/ejoc.201601394

upstream raw materials:

trimethylsilyl cyanide

atropine

atropine