OTAVA-BB 7020402312

Base Information

• Chemical Name: OTAVA-BB 7020402312
• CAS No.: 887468-70-4
• Molecular Formula: C₁₄H₁₀N₂O₃
• Molecular Weight: 254.245
• Mol file: 887468-70-4.mol

Synonyms:OTAVA-BB 7020402312

Chemical Property of OTAVA-BB 7020402312

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of OTAVA-BB 7020402312

There total 6 articles about OTAVA-BB 7020402312 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7-methoxy-3-(4-methoxyphenyl)-3-hydroquinazolin-4-one (880450-36-2) → 7-hydroxy-3-(4-hydroxyphenyl)-3-hydroquinazolin-4-one (887468-70-4)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 264.5h;

Reference yield:

7-methoxy-2H-benzo[d][1,3]oxazine-2,4(1H)-dione (128076-63-1) → 7-hydroxy-3-(4-hydroxyphenyl)-3-hydroquinazolin-4-one (887468-70-4)

Guidance literature:

Multi-step reaction with 3 steps

1: DMAP / N,N-dimethyl-acetamide / 24 h / 110 °C

2: 4 h / Heating

With dmap; In N,N-dimethyl acetamide;

DOI:10.1021/jm0509389

Reference yield:

6-methoxyisatin (52351-75-4) → 7-hydroxy-3-(4-hydroxyphenyl)-3-hydroquinazolin-4-one (887468-70-4)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. NaOH; aq. H₂O₂ / 0.17 h / 100 °C

2: tetrahydrofuran / 0 - 20 °C

3: DMAP / N,N-dimethyl-acetamide / 24 h / 110 °C

4: 4 h / Heating

With dmap; sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; N,N-dimethyl acetamide;

DOI:10.1021/jm0509389

upstream raw materials:

7-methoxy-3-(4-methoxyphenyl)-3-hydroquinazolin-4-one

7-methoxy-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

6-methoxyisatin

m-anisidine hydrochloride

Downstream raw materials:

prop-2-enyl 3-{[3-(4-hydroxyphenyl)-4-oxo-3-hydroquinazolin-7-yloxy]methyl} benzoate

methylethyl 3-((3-(4-hydroxyphenyl)-4-oxo-3-hydroquinazolin-7-yloxy)methyl)benzoate