1616114-00-1

Base Information

• Chemical Name: 1616114-00-1
• CAS No.: 1616114-00-1
• Molecular Formula: C19H17Br2NO
• Molecular Weight: 435.15
• Mol file: 1616114-00-1.mol

Synonyms:1-(2,7-Dibromospiro[fluorene-9,4'-piperidin]-1'-yl)ethanone

Chemical Property of 1616114-00-1

Chemical Property:

• PSA: 20.31000
• LogP: 5.05830
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(2,7-Dibromospiro[fluorene-9,4'-piperidin]-1'-yl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1616114-00-1

There total 2 articles about 1616114-00-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.4%

2,7-dibromospiro[fluorene-9,4'-piperidine] hydrochloride + acetyl chloride (75-36-5) → 1-(2,7-dibromospiro[fluorene-9,4'-piperidine]-1'-yl)ethanone (1616114-00-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

tert-butyl 2,7-dibromospiro[fluorene-9,4'-piperidine]-1'-carboxylate (1616113-98-4) + acetic anhydride (108-24-7) + acetic acid (64-19-7,77671-22-8) + acetyl chloride (75-36-5) → 1-(2,7-dibromospiro[fluorene-9,4'-piperidine]-1'-yl)ethanone (1616114-00-1)

Guidance literature:

at 100 ℃; for 7h;

Reference yield: 80.0%

1-(2,7-dibromospiro[fluorene-9,4'-piperidine]-1'-yl)ethanone (1616114-00-1) + (2R,3S,4R,5S,6R)-2-ethynyl-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol (388578-39-0) → 1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone (1616113-45-1)

Guidance literature:

With copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100 ℃; for 4.5h; Concentration; Time; Inert atmosphere;

upstream raw materials:

acetyl chloride

tert-butyl 2,7-dibromospiro[fluorene-9,4'-piperidine]-1'-carboxylate

acetic anhydride

acetic acid

Downstream raw materials:

1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone