2-(2-Bromothiazol-4-yl)ethanol

Base Information

• Chemical Name: 2-(2-Bromothiazol-4-yl)ethanol
• CAS No.: 263169-24-0
• Molecular Formula: C₅H₆BrNOS
• Molecular Weight: 208.079
• European Community (EC) Number: 846-032-6
• DSSTox Substance ID: DTXSID00709809
• Wikidata: Q82644938
• Mol file: 263169-24-0.mol

Synonyms:2-(2-Bromothiazol-4-yl)ethanol;263169-24-0;2-(2-bromo-1,3-thiazol-4-yl)ethanol;2-(2-Bromo-1,3-thiazol-4-yl)ethan-1-ol;2-(2-bromothiazol-4-yl)ethan-1-ol;SCHEMBL2892691;DTXSID00709809;PYJGKNDTFRUDRN-UHFFFAOYSA-N;MFCD20924395;AM85686;C11083;EN300-269687;A1-33135

Chemical Property of 2-(2-Bromothiazol-4-yl)ethanol

Chemical Property:

• PSA: 61.36000
• LogP: 1.44040
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 206.93535
• Heavy Atom Count: 9
• Complexity: 93

Purity/Quality:

99.00% ^*data from raw suppliers

2-(2-Bromothiazol-4-yl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=C(S1)Br)CCO

Technology Process of 2-(2-Bromothiazol-4-yl)ethanol

There total 4 articles about 2-(2-Bromothiazol-4-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

methyl 2-(2-bromothiazol-4-yl)acetate (1261589-82-5) → 2-(2-bromothiazol-4-yl)ethanol (263169-24-0)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 0 - 20 ℃; for 3h;

Reference yield: 58.63%

ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate (56355-79-4) → 2-(2-bromothiazol-4-yl)ethanol (263169-24-0)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 0 - 25 ℃; for 3h;

Reference yield:

(2-amino-thiazol-4-yl)-acetic acid methyl ester (64987-16-2) → 2-(2-bromothiazol-4-yl)ethanol (263169-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tert.-butylnitrite; copper(I) bromide / acetonitrile / 0 - 70 °C

2: sodium tetrahydroborate; ethanol / 3 h / 0 - 20 °C

With sodium tetrahydroborate; tert.-butylnitrite; ethanol; copper(I) bromide; In acetonitrile;

upstream raw materials:

ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate

methyl 2-(2-bromothiazol-4-yl)acetate

(2-amino-thiazol-4-yl)-acetic acid methyl ester

ethyl 2-amino-1,3-thiazol-4-acetate