AC710

Base Information

• Chemical Name: AC710
• CAS No.: 1351522-04-7
• Molecular Formula: C31H42N6O4
• Molecular Weight: 562.7
• Mol file: 1351522-04-7.mol

Synonyms:AC710;N-[4-[[[[5-(1,1-Dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide;5-[(1-Ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-N-[4-({[5-(2-methyl-2-propanyl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-2-pyridinecarboxamide

Chemical Property of AC710

Chemical Property:

• Boiling Point: 580.4±50.0 °C(Predicted)
• PKA: 10.91±0.70(Predicted)
• PSA: 121.62000
• Density: 1.180±0.06 g/cm3(Predicted)
• LogP: 6.84060

Purity/Quality:

99%, ^*data from raw suppliers

AC710 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: AC 710 is a globally selective inhibitor of platelet-derived growth factor receptor-family kinases and has been shown to have potential anti-arthritic theapeutic use.

Technology Process of AC710

There total 4 articles about AC710 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-aminophenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (852668-37-2) + 5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinic acid (1351503-95-1) → N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide (1351522-04-7)

Guidance literature:

5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; for 0.166667h;

1-(4-aminophenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/ml300214g

Reference yield:

5-fluoropicolinonitrile (327056-62-2) → N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide (1351522-04-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydroxide; water / ethanol / Reflux

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.17 h

3.2: 3 h / 20 °C

With water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ml300214g

Reference yield:

1-ethyl-2,2,6,6-tetramethylpiperidin-4-ol (106590-40-3) → N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide (1351522-04-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydroxide; water / ethanol / Reflux

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.17 h

3.2: 3 h / 20 °C

With water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ml300214g

upstream raw materials:

5-fluoropicolinonitrile

1-(4-aminophenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea

5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinic acid

1-ethyl-2,2,6,6-tetramethylpiperidin-4-ol

Downstream raw materials:

N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide methanesulfonate salt

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