(1-Methyl-1H-pyrazol-5-yl)acetonitrile

Base Information

• Chemical Name: (1-Methyl-1H-pyrazol-5-yl)acetonitrile
• CAS No.: 1071814-43-1
• Molecular Formula: C₆H₇N₃
• Molecular Weight: 121.142
• Hs Code.: 2933199090
• Mol file: 1071814-43-1.mol

Synonyms:(1-Methyl-1H-pyrazol-5-yl)acetonitrile;2-(1-methyl-1H-pyrazol-5-yl)acetonitrile;1-methyl-1H-pyrazole-5-acetonitrile

Chemical Property of (1-Methyl-1H-pyrazol-5-yl)acetonitrile

Chemical Property:

• PSA: 41.61000
• LogP: 0.48618

Purity/Quality:

97% ^*data from raw suppliers

(1-Methyl-1H-pyrazol-5-yl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1-Methyl-1H-pyrazol-5-yl)acetonitrile

There total 6 articles about (1-Methyl-1H-pyrazol-5-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

potassium cyanide + 5-(chloromethyl)-1-methyl-1H-pyrazole (84547-63-7) → 2-(1-methyl-1H-pyrazol-5-yl)acetonitrile (1071814-43-1)

Guidance literature:

In water; acetonitrile; at 50 ℃; for 10h;

Reference yield:

tert-butyl 2-cyano-2-(1-methyl-1H-pyrazol-5-yl)acetate → 2-(1-methyl-1H-pyrazol-5-yl)acetonitrile (1071814-43-1)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; at 130 ℃; for 0.25h; Microwave irradiation;

Reference yield:

sodium cyanide (143-33-9,25596-52-5) + 5-(chloromethyl)-1-methyl-1H-pyrazole (84547-63-7) → 2-(1-methyl-1H-pyrazol-5-yl)acetonitrile (1071814-43-1)

Guidance literature:

In dimethyl sulfoxide; at 50 ℃; for 3h;

upstream raw materials:

sodium cyanide

5-(chloromethyl)-1-methyl-1H-pyrazole

(1-methyl-1H-pyrazol-5-yl)methanol

1-methyl-1H-pyrazole-5-carboxylic acid

Downstream raw materials:

2-(1-methyl-1H-pyrazol-5-yl)acetic acid

5-(4-chloro-3-methoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

5-(4-chloro-3-isopropoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

5-(3-ethoxy-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one