5-(4-chloro-3-isopropoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Base Information

• Chemical Name: 5-(4-chloro-3-isopropoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
• CAS No.: 1607023-26-6
• Molecular Formula: C₁₉H₁₈ClN₅O₂
• Molecular Weight: 383.837
• Mol file: 1607023-26-6.mol

Synonyms:5-(4-chloro-3-isopropoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Chemical Property of 5-(4-chloro-3-isopropoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-(4-chloro-3-isopropoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

There total 9 articles about 5-(4-chloro-3-isopropoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-methyl-1'H,2H-3,4'-bipyrazol-5'-amine (1607024-50-9) + ethyl 3-(4-chloro-3-isopropoxyphenyl)-3-oxopropanoate (1607024-67-8) → 5-(4-chloro-3-isopropoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one (1607023-26-6)

Guidance literature:

With toluene-4-sulfonic acid; In butan-1-ol; for 1h; Reflux;

Reference yield:

4-chloro-3-hydroxybenzoic acid (34113-69-4) → 5-(4-chloro-3-isopropoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one (1607023-26-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

2.1: sodium hydroxide; water / methanol / 10 h / 55 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 20 °C

3.2: 0 - 20 °C

4.1: toluene-4-sulfonic acid / butan-1-ol / 1 h / Reflux

With water; potassium carbonate; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

5-(chloromethyl)-1-methyl-1H-pyrazole (84547-63-7) → 5-(4-chloro-3-isopropoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one (1607023-26-6)

Guidance literature:

Multi-step reaction with 4 steps

1: acetonitrile; water / 10 h / 50 °C

2: toluene / 4 h / 85 °C

3: acetic acid; hydrazine hydrate / 4 h / 80 °C

4: toluene-4-sulfonic acid / butan-1-ol / 1 h / Reflux

With toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In water; toluene; acetonitrile; butan-1-ol;

upstream raw materials:

4-chloro-3-hydroxybenzoic acid

(1-methyl-1H-pyrazol-5-yl)methanol

5-(chloromethyl)-1-methyl-1H-pyrazole

2-(1-methyl-1H-pyrazol-5-yl)acetonitrile