6-Chloro-[3,4'-bipyridine]-5-carbonitrile

Base Information

Chemical Name:6-Chloro-[3,4'-bipyridine]-5-carbonitrile
CAS No.:70959-58-9
Molecular Formula:C11H6ClN3
Molecular Weight:215.642
Hs Code.:
DSSTox Substance ID:DTXSID40876620
Nikkaji Number:J292.937F
Wikidata:Q82858275
Mol file:70959-58-9.mol

Synonyms:70959-58-9;6-Chloro-[3,4'-bipyridine]-5-carbonitrile;SCHEMBL7272197;DTXSID40876620;AKOS022651898;2-Chloro-5-(pyridin-4-yl)nicotinonitrile;6-Chloro-3,4'-bipyridine-5-carbonitrile;[3,4'-BIPYRIDINE]-5-CARBONITRILE,6-CHLORO-

Suppliers and Price of 6-Chloro-[3,4'-bipyridine]-5-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-CHLORO-5-(PYRIDIN-4-YL)NICOTINONITRILE 95.00%
5MG
$ 497.70

Alichem
2-Chloro-5-(pyridin-4-yl)nicotinonitrile
1g
$ 2866.05

Alichem
2-Chloro-5-(pyridin-4-yl)nicotinonitrile
250mg
$ 980.00

Total 3 raw suppliers

Chemical Property of 6-Chloro-[3,4'-bipyridine]-5-carbonitrile

Chemical Property:

PSA：49.57000
LogP:2.66868
XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:215.0250249
Heavy Atom Count:15
Complexity:254

Purity/Quality:

99% ^*data from raw suppliers

2-CHLORO-5-(PYRIDIN-4-YL)NICOTINONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=CC=C1C2=CC(=C(N=C2)Cl)C#N

Technology Process of 6-Chloro-[3,4'-bipyridine]-5-carbonitrile

There total 2 articles about 6-Chloro-[3,4'-bipyridine]-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 405224-23-9
5-bromo-2-chloropyridine-3-carbonitrile

: 70959-58-9
2-chloro-3-cyano-5-(4-pyridinyl)pyridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In methanol; water; toluene; Inert atmosphere;
DOI:10.1016/j.bmcl.2018.02.054

Reference yield:

: 405224-22-8
2-hydroxy-3-cyano-5-bromopyridine

: 70959-58-9
2-chloro-3-cyano-5-(4-pyridinyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 5 h / 0 °C / Reflux

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / toluene; methanol; water / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; trichlorophosphate; In methanol; water; toluene;
DOI:10.1016/j.bmcl.2018.02.054