4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide

Base Information

Chemical Name:4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide
CAS No.:1446111-75-6
Molecular Formula:C₂₂H₁₆ClN₇OS
Molecular Weight:461.934
Hs Code.:
Mol file:1446111-75-6.mol

Synonyms:4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide

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Chemical Property of 4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide

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Technology Process of 4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide

There total 14 articles about 4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1318242-98-6
4-amino-thieno[3,2-d]pyrimidine-7-carboxylic acid

: 1446113-38-7
N⁴-(4-chlorophenyl)-7-methylquinazoline-4,8-diamine

: 1446111-75-6
4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: 4-amino-thieno[3,2-d]pyrimidine-7-carboxylic acid; With diethyl chlorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

N⁴-(4-chlorophenyl)-7-methylquinazoline-4,8-diamine; In N,N-dimethyl-formamide; at 40 ℃; for 10h;

Reference yield:

: 75844-40-5
7-methyl-quinazolin-4(3H)-one

: 1446111-75-6
4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; bromine / methanol / 5 h / 20 °C

2.1: sulfuric acid; potassium nitrate / 0.33 h / 80 °C

3.1: trichlorophosphate / 4 h / 130 °C

4.1: isopropyl alcohol / 90 °C / Sealed tube

5.1: palladium 10% on activated carbon; hydrogen / ethanol / 8 h

6.1: diethyl chlorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 0 °C

6.2: 10 h / 40 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; bromine; diethyl chlorophosphate; acetic acid; potassium nitrate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 26830-96-6
5-methyl-2-cyanoaniline

: 1446111-75-6
4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide / ethanol / 8 h / Reflux

2.1: 6 h / 100 °C

3.1: acetic acid; bromine / methanol / 5 h / 20 °C

4.1: sulfuric acid; potassium nitrate / 0.33 h / 80 °C

5.1: trichlorophosphate / 4 h / 130 °C

6.1: isopropyl alcohol / 90 °C / Sealed tube

7.1: palladium 10% on activated carbon; hydrogen / ethanol / 8 h

8.1: diethyl chlorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 0 °C

8.2: 10 h / 40 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; bromine; diethyl chlorophosphate; acetic acid; potassium nitrate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate; In methanol; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;