7-METHYLQUINAZOLIN-4(1H)-ONE

Base Information

• Chemical Name: 7-METHYLQUINAZOLIN-4(1H)-ONE
• CAS No.: 75844-40-5
• Molecular Formula: C9H8 N2 O
• Molecular Weight: 160.175
• Hs Code.: 2933990090
• Mol file: 75844-40-5.mol

Synonyms:4(1H)-Quinazolinone,7-methyl- (9CI); NSC 319035

Chemical Property of 7-METHYLQUINAZOLIN-4(1H)-ONE

Chemical Property:

• Vapor Pressure: 0.000559mmHg at 25°C
• Boiling Point: 311.6°C at 760 mmHg
• Flash Point: 142.2°C
• PSA: 45.75000
• Density: 1.26g/cm³
• LogP: 1.23150
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

7-Methylquinazolin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-METHYLQUINAZOLIN-4(1H)-ONE

There total 16 articles about 7-METHYLQUINAZOLIN-4(1H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-amino-4-methylbenzamide (39549-79-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 7-methyl-quinazolin-4(3H)-one (75844-40-5)

Guidance literature:

With Imidazole hydrochloride; at 150 ℃; for 13h;

DOI:10.1016/j.tet.2020.131480

Reference yield: 93.0%

→ 7-methyl-quinazolin-4(3H)-one (75844-40-5)

Guidance literature:

With ammonium hydroxide; palladium dichloride; at 90 ℃; for 0.166667h; Microwave irradiation; Green chemistry;

Reference yield: 91.0%

formic acid (64-18-6) + 2-amino-4-methylbenzamide (39549-79-6) → 7-methyl-quinazolin-4(3H)-one (75844-40-5)

Guidance literature:

at 100 ℃; for 6h;

upstream raw materials:

formic acid

2-amino-4-methylbenzamide

5-methyl-2-cyanoaniline

formamide

Downstream raw materials:

6-bromo-7-methylquinazolin-4(3H)-one

5-bromo-7-methyl-8-nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine

7-methyl-N⁴-(3-(trifluoromethyl)phenyl)quinazoline-4,8-diamine

4-(8-(3-(1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)pyridin-2-ylamino)-7-methylquinazolin-4-ylamino)benzonitrile

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