6-Bromo-7-methylquinazolin-4(3H)-one

Base Information

• Chemical Name: 6-Bromo-7-methylquinazolin-4(3H)-one
• CAS No.: 943605-85-4
• Molecular Formula: C9H7BrN2O
• Molecular Weight: 239.06868
• Hs Code.: 2933990090
• Mol file: 943605-85-4.mol

Synonyms:4(3H)-Quinazolinone, 6-bromo-7-methyl-; 6-bromo-7-methylquinazolin-4(3H)-one

Chemical Property of 6-Bromo-7-methylquinazolin-4(3H)-one

Chemical Property:

• Vapor Pressure: 2.61E-08mmHg at 25°C
• Boiling Point: 450.6°C at 760 mmHg
• Flash Point: 226.3°C
• PSA: 46.01000
• Density: 1.72g/cm³
• LogP: 2.40630

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-7-methylquinazolin-4(3H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-7-methylquinazolin-4(3H)-one

There total 4 articles about 6-Bromo-7-methylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

7-methyl-quinazolin-4(3H)-one (75844-40-5) → 6-bromo-7-methylquinazolin-4(3H)-one (943605-85-4)

Guidance literature:

7-methyl-quinazolin-4(3H)-one; With methanol; acetic acid; at 20 ℃; for 0.0833333h;

With bromine; at 20 ℃; for 3h;

Reference yield: 50.0%

2-amino-5-bromo-4-methylbenzoic acid (106976-24-3) + formamide (77287-34-4,77287-35-5,60100-09-6) → 6-bromo-7-methylquinazolin-4(3H)-one (943605-85-4)

Guidance literature:

2-amino-5-bromo-4-methylbenzoic acid; With ammonia; for 1h; Heating / reflux;

formamide; for 4h; Heating / reflux;

With water; for 0.5h; Heating / reflux;

Reference yield:

2-amino-4-methylbenzamide (39549-79-6) → 6-bromo-7-methylquinazolin-4(3H)-one (943605-85-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 6 h / 100 °C

2: acetic acid; bromine / methanol / 5 h / 20 °C

With bromine; acetic acid; In methanol;

upstream raw materials:

7-methyl-quinazolin-4(3H)-one

2-amino-5-bromo-4-methylbenzoic acid

formamide

2-amino-4-methylbenzamide

Downstream raw materials:

6-bromo-7-methyl-8-nitroquinazolin-4(3H)-one

4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide

6-bromo-N-(4-chlorophenyl)-7-methyl-8-nitroquinazolin-4-amine

N⁴-(4-chlorophenyl)-7-methylquinazoline-4,8-diamine