(S)-4-Benzyloxy-3-methoxy-N-(1-phenylethyl)benzeneacetamide

Base Information

Chemical Name:(S)-4-Benzyloxy-3-methoxy-N-(1-phenylethyl)benzeneacetamide
CAS No.:192190-36-6
Molecular Formula:C24H25NO3
Molecular Weight:375.4602
Hs Code.:
DSSTox Substance ID:DTXSID70447029
Wikidata:Q82265806
Mol file:192190-36-6.mol

Synonyms:192190-36-6;(S)-4-Benzyloxy-3-methoxy-N-(1-phenylethyl)benzeneacetamide;2-(3-methoxy-4-phenylmethoxyphenyl)-N-[(1S)-1-phenylethyl]acetamide;DTXSID70447029;YHOQRDYKTVTNKJ-SFHVURJKSA-N

Suppliers and Price of (S)-4-Benzyloxy-3-methoxy-N-(1-phenylethyl)benzeneacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-4-Benzyloxy-3-methoxy-N-(1-phenylethyl)benzeneacetamide
100mg
$ 1320.00

TRC
(S)-4-Benzyloxy-3-methoxy-N-(1-phenylethyl)benzeneacetamide
10mg
$ 165.00

Medical Isotopes, Inc.
(S)-4-Benzyloxy-3-methoxy-N-(1-phenylethyl)benzeneacetamide
100 mg
$ 2200.00

Total 1 raw suppliers

Chemical Property of (S)-4-Benzyloxy-3-methoxy-N-(1-phenylethyl)benzeneacetamide

Chemical Property:

PSA：51.05000
LogP:5.53440
Solubility.:Dichloromethane, Ethyl Acetate
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:375.18344366
Heavy Atom Count:28
Complexity:457

Purity/Quality:: (S)-4-Benzyloxy-3-methoxy-N-(1-phenylethyl)benzeneacetamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)NC(=O)CC2=CC(=C(C=C2)OCC3=CC=CC=C3)OC
Isomeric SMILES:C[C@@H](C1=CC=CC=C1)NC(=O)CC2=CC(=C(C=C2)OCC3=CC=CC=C3)OC

Technology Process of (S)-4-Benzyloxy-3-methoxy-N-(1-phenylethyl)benzeneacetamide

There total 1 articles about (S)-4-Benzyloxy-3-methoxy-N-(1-phenylethyl)benzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.8%

: 2627-86-3
(S)-1-phenyl-ethylamine

: 54313-35-8
2-(4-(benzyloxy)-3-methoxyphenyl)acetyl chloride

: 192190-36-6
N-((S)-1-phenylethyl)-2-(4-benzyloxy-3-methoxyphenyl)acetamide

Guidance literature:: With sodium carbonate; In diethyl ether; at 0 - 5 ℃; for 1h;
DOI:10.3987/com-97-7782

Reference yield: 87.0%

: 192190-36-6
N-((S)-1-phenylethyl)-2-(4-benzyloxy-3-methoxyphenyl)acetamide

: 192190-37-7
N-((S)-1-phenylethyl)-2-(4-benzyloxy-3-methoxyphenyl)ethylamine

Guidance literature:: With borane-THF; boron trifluoride diethyl etherate; In tetrahydrofuran; at 70 ℃; for 2.5h;
DOI:10.3987/com-97-7782

Reference yield:

: 192190-36-6
N-((S)-1-phenylethyl)-2-(4-benzyloxy-3-methoxyphenyl)acetamide

: 192190-44-6
(S)-1-(5-hydroxy-2-methoxybenzyl)-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / 47percent BF₃*ether, 1.0M BH₃*THF / tetrahydrofuran / 2.5 h / 70 °C

2: 88.9 percent / 5percent aq. Na₂CO₃ / diethyl ether / 2 h / 0 - 5 °C

3: POCl₃ / toluene / 3.5 h / Heating

4: NaBH₄ / methanol / 2 h / -78 °C

5: 84.9 percent / H₂, conc. HCl / 10percent Pd/C / ethanol / 23 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; borane-THF; boron trifluoride diethyl etherate; hydrogen; sodium carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; toluene;
DOI:10.3987/com-97-7782