2-METHOXY-3-THENOYLPYRIDINE

Base Information

• Chemical Name: 2-METHOXY-3-THENOYLPYRIDINE
• CAS No.: 332134-11-9
• Molecular Formula: C₁₁H₉NO₂S
• Molecular Weight: 219.264
• Hs Code.: 2934999090
• Mol file: 332134-11-9.mol

Synonyms:2-METHOXY-3-THENOYLPYRIDINE

Chemical Property of 2-METHOXY-3-THENOYLPYRIDINE

Chemical Property:

• Vapor Pressure: 3.11E-06mmHg at 25°C
• Melting Point: 64.1-65.0 °C
• Boiling Point: 388.2°C at 760 mmHg
• PKA: 1.09±0.10(Predicted)
• Flash Point: 188.6°C
• PSA: 67.43000
• Density: 1.258g/cm³
• LogP: 2.38270

Purity/Quality:

95% ^*data from raw suppliers

2-Methoxy-3-thenoylpyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHOXY-3-THENOYLPYRIDINE

There total 3 articles about 2-METHOXY-3-THENOYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-methoxypyridine (1628-89-3) + 2-Thiophenecarbonyl chloride (5271-67-0) → (2-methoxypyridin-3-yl)(thiophen-2-yl)methanone (332134-11-9)

Guidance literature:

2-methoxypyridine; With aluminum tris-(tert-butyl-(1-isopropyl-2,2-dimethyl-propyl)amide)-tris(lithium chloride); In tetrahydrofuran; at 25 ℃; for 3h; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; at -30 ℃; for 0.25h; Inert atmosphere;

2-Thiophenecarbonyl chloride; With copper(I) cyanide*2 lithium chloride; In tetrahydrofuran; at -30 - 25 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.200804966

Reference yield:

2-chloro-3-(2-thiophenecarbonyl)pyridine (125035-34-9) → (2-methoxypyridin-3-yl)(thiophen-2-yl)methanone (332134-11-9)

Guidance literature:

With sodium methylate; In methanol; water;

Reference yield:

2-Chloronicotinoyl chloride (49609-84-9) → (2-methoxypyridin-3-yl)(thiophen-2-yl)methanone (332134-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: carbon disulfide / aluminium trichloride / thiophene; ethyl acetate

2: sodium methylate / methanol; water

With carbon disulfide; sodium methylate; aluminium trichloride; In thiophene; methanol; water; ethyl acetate;

upstream raw materials:

2-chloro-3-(2-thiophenecarbonyl)pyridine

2-methoxypyridine

2-Thiophenecarbonyl chloride

2-Chloronicotinoyl chloride

Refernces

• 1、 -. "Quinuclidine compounds and drugs containing the same as the active ingredient". . . Retrieved 2008/06/13.