(3β,15α,17β)-15,17-Bis-O-(tert-butyldimethylsilyloxy) Androst-5-en-3-ol

Base Information

• Chemical Name: (3β,15α,17β)-15,17-Bis-O-(tert-butyldimethylsilyloxy) Androst-5-en-3-ol
• CAS No.: 65429-25-6
• Molecular Formula: C₃₁H₅₈O₃Si₂
• Molecular Weight: 534.971
• Mol file: 65429-25-6.mol

Synonyms:(3β,15α,17β)-15,17-Bis-O-(tert-butyldimethylsilyloxy) Androst-5-en-3-ol;(3β,15α,17β)-15,17-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]androst-5-en-3-ol

Chemical Property of (3β,15α,17β)-15,17-Bis-O-(tert-butyldimethylsilyloxy) Androst-5-en-3-ol

Chemical Property:

• PSA: 38.69000
• LogP: 8.70080
• Solubility.: Chloroform, Dichloromethane, Ether, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

(3β,15α,17β)-15,17-Bis-O-(tert-butyldimethylsilyloxy)Androst-5-en-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of Testosterone metabolties.

Technology Process of (3β,15α,17β)-15,17-Bis-O-(tert-butyldimethylsilyloxy) Androst-5-en-3-ol

There total 3 articles about (3β,15α,17β)-15,17-Bis-O-(tert-butyldimethylsilyloxy) Androst-5-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β-Acetoxy-5-androsten-15α,17β-diol-bis-(tert.-butyldimethylsilyl)-ether (65429-24-5) → 5-Androsten-3β,15α,17β-triol-15,17-bis-(tert.-butyldimethylsilyl)-ether (65429-25-6)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1248/cpb.25.2650

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 5-Androsten-3β,15α,17β-triol-15,17-bis-(tert.-butyldimethylsilyl)-ether (65429-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) BF₃-Et₂O, THF, Et₂O, (ii) /BRN= 505999/, imidazole, DMF

2: aq. KOH / methanol; tetrahydrofuran

With potassium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1248/cpb.25.2650

Reference yield:

(1aR,3aR,3bS,5aS,6S,8S,8aS,8bR,10R,10aR)-6-(tert-Butyl-dimethyl-silanyloxy)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-8-ol (61252-35-5) → 5-Androsten-3β,15α,17β-triol-15,17-bis-(tert.-butyldimethylsilyl)-ether (65429-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) BF₃-Et₂O, THF, Et₂O, (ii) /BRN= 505999/, imidazole, DMF

2: aq. KOH / methanol; tetrahydrofuran

With potassium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1248/cpb.25.2650

upstream raw materials:

3β-Acetoxy-5-androsten-15α,17β-diol-bis-(tert.-butyldimethylsilyl)-ether

tert-butyldimethylsilyl chloride

(1aR,3aR,3bS,5aS,6S,8S,8aS,8bR,10R,10aR)-6-(tert-Butyl-dimethyl-silanyloxy)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-8-ol

Downstream raw materials:

15α,17β-Dihydroxy-4-androsten-3-on-bis-(tert.-butyldimethylsilyl)-ether

15alpha-Hydroxytestosterone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 65429-25-6 (3β,15α,17β)-15,17-Bis-O-(tert-butyldimethylsilyloxy) Androst-5-en-3-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send