1,2-Dihydro-5-methyl-2-(p-tolyl)-3H-indazol-3-one

Base Information

• Chemical Name: 1,2-Dihydro-5-methyl-2-(p-tolyl)-3H-indazol-3-one
• CAS No.: 17049-55-7
• Molecular Formula: C15H14N2O
• Molecular Weight: 238.289
• Hs Code.: 2933990090
• Mol file: 17049-55-7.mol

Synonyms:1,2-Dihydro-5-methyl-2-(p-tolyl)-3H-indazol-3-one

Chemical Property of 1,2-Dihydro-5-methyl-2-(p-tolyl)-3H-indazol-3-one

Chemical Property:

• PSA: 37.79000
• LogP: 2.93560

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Dihydro-5-methyl-2-(p-tolyl)-3H-indazol-3-one

There total 4 articles about 1,2-Dihydro-5-methyl-2-(p-tolyl)-3H-indazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1,2-di(p-tolyl)diazene (501-60-0,21650-54-4,30926-02-4) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) → 2-(p-tolyl)-5-methylindazolone (17049-55-7)

Guidance literature:

With acetic acid; p-benzoquinone; palladium dichloride; at 100 ℃; for 24h; regioselective reaction; Sealed tube;

DOI:10.1002/cctc.201700679

Reference yield:

1-methyl-4-nitrobenzene (99-99-0) → 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline (33900-97-9) + p-toluidine (106-49-0,12221-03-3) + 2-(p-tolyl)-5-methylindazolone (17049-55-7) + 1,2-di(p-tolyl)diazene (501-60-0,21650-54-4,30926-02-4)

Guidance literature:

With pyridine; aluminum oxide; iron pentacarbonyl; carbon monoxide; Azobenzene; In chlorobenzene; at 180 ℃; for 0.333333h; under 105008 Torr; Product distribution; other reagent Fe(CO)5/Al₂O₃ + PdCl₂Py₂; other temperature: 190, 200, 220 deg C; other pressure: 8 MPa; other time 30 min;

DOI:10.1007/BF01435377

Reference yield:

p-toluidine (106-49-0,12221-03-3) → 2-(p-tolyl)-5-methylindazolone (17049-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(I) bromide; pyridine / toluene / 24 h / 60 °C

2: palladium dichloride; p-benzoquinone; acetic acid / 24 h / 100 °C / Sealed tube

With pyridine; acetic acid; p-benzoquinone; copper(I) bromide; palladium dichloride; In toluene;

DOI:10.1002/cctc.201700679

upstream raw materials:

1-methyl-4-nitrobenzene

1,2-di(p-tolyl)diazene

molybdenum hexacarbonyl

p-toluidine