33900-97-9

Basic information

• Product Name: 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline
• Synonyms: 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline
• CAS NO: 33900-97-9
• Molecular Weight: 266.299
• Mol File: 33900-97-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline(33900-97-9)
• EPA Substance Registry System: 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline(33900-97-9)

Safety Data

• Hazardous Substances Data: 33900-97-9(Hazardous Substances Data)

Upstream product

• 7342-77-0 1,3-di(4-tolyl)-2,4-dioxo-1,3-diazete 
• 99-99-0 1-methyl-4-nitrobenzene 
• 124-38-9 carbon dioxide 
• 106-49-0 p-toluidine 
• 501-60-0 1,2-di(p-tolyl)diazene 
• 201230-82-2 carbon monoxide 
• 29289-13-2 2-iodo-4-methylaniline 
• 622-58-2 p-Tolylisocyanate 
• 608-05-9 5-methyl-indole-2,3-dione 
• 13037-22-4 methyl (N-(4-methylphenyl))dithiocarbamate 
• 86672-61-9 Potassium; 2-amino-5-methyl-benzoate 

Downstream Products

• 2941-78-8 2-Amino-5-methylbenzoic acid 

Relevant articles and documents

Oxidative Rearrangement of Isatins with Arylamines Using H2O2 as Oxidant: A Facile Synthesis of Quinazoline-2,4-diones and Evaluation of Their Antibacterial Activity

A green and highly efficient synthetic method for the synthesis of quinazoline-2,4-diones with hydrogen peroxide as the terminal oxidant has been developed. The reaction features the mild reaction conditions, broad substrate scope, metal-free catalysts, and sole byproduct water. A plausible mechanism for this process was proposed. Moreover, an antibacterial activity study was performed to evaluate the antimicrobial activities towards two Gram-negative bacterial strains (Escherichia coli, and Klebsiella pneumonia) and two Gram-positive bacterial strains (Staphylococcus epidermidis, and Staphylococcus aureus) using the Broth microdilution method.

Carbonylation of nitro and azo compounds in the presence of iron carbonyl catalysts

The reactions of nitro and azo compounds with carbon monoxide were studied in the presence of iron carbonyl catalysts. It was shown that these catalytic systems differ substantially from Pd- and Rh-containing catalysts. In the case of the iron catalysts, the products of coupling of molecules are formed as intermediates and azo compounds are the final reaction products. The reactions involving the palladium and rhodium catalysts proceed without the intermediate formation of the coupling products and lead to isocyanates or carbamates. When combined using PdCh and Fe(CO)5/Al2Oj, the catalysts inhibit each other, especially in the presence of pyridine.