2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline

Base Information

• Chemical Name: 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline
• CAS No.: 33900-97-9
• Molecular Formula: C₁₆H₁₄N₂O₂
• Molecular Weight: 266.299
• Mol file: 33900-97-9.mol

Synonyms:2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline

Chemical Property of 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline

There total 8 articles about 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

carbon monoxide (201230-82-2) + 2-iodo-4-methylaniline (29289-13-2) + p-Tolylisocyanate (622-58-2,374675-64-6) → 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline (33900-97-9)

Guidance literature:

With palladium diacetate; potassium carbonate; 1,4-di(diphenylphosphino)-butane; In tetrahydrofuran; at 70 - 80 ℃; for 12h; under 15514.9 Torr;

DOI:10.1021/jo991922r

Reference yield: 73.0%

5-methyl-indole-2,3-dione (608-05-9) + p-toluidine (106-49-0,12221-03-3) → 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline (33900-97-9)

Guidance literature:

With dihydrogen peroxide; sodium hydrogencarbonate; In methanol; water; at 20 ℃; for 8h; Green chemistry;

DOI:10.1002/cjoc.201700280

Reference yield:

1-methyl-4-nitrobenzene (99-99-0) → 2,4-dioxo-3-(p-tolyl)-6-methyl-1,2,3,4-tetrahydroquinazoline (33900-97-9) + p-toluidine (106-49-0,12221-03-3) + 2-(p-tolyl)-5-methylindazolone (17049-55-7) + 1,2-di(p-tolyl)diazene (501-60-0,21650-54-4,30926-02-4)

Guidance literature:

With pyridine; aluminum oxide; iron pentacarbonyl; carbon monoxide; Azobenzene; In chlorobenzene; at 180 ℃; for 0.333333h; under 105008 Torr; Product distribution; other reagent Fe(CO)5/Al₂O₃ + PdCl₂Py₂; other temperature: 190, 200, 220 deg C; other pressure: 8 MPa; other time 30 min;

DOI:10.1007/BF01435377

upstream raw materials:

1,3-di(4-tolyl)-2,4-dioxo-1,3-diazete

methyl (N-(4-methylphenyl))dithiocarbamate

Potassium; 2-amino-5-methyl-benzoate

1-methyl-4-nitrobenzene

Downstream raw materials:

2-Amino-5-methylbenzoic acid