5-Bromo-2-chloro-4-(trifluoromethyl)pyrimidine

Base Information

• Chemical Name: 5-Bromo-2-chloro-4-(trifluoromethyl)pyrimidine
• CAS No.: 785777-92-6
• Molecular Formula: C₅HBrClF₃N₂
• Molecular Weight: 261.429
• Hs Code.: 2933599590
• European Community (EC) Number: 890-876-8
• DSSTox Substance ID: DTXSID50465509
• Nikkaji Number: J2.123.932A
• Wikidata: Q82291510
• Mol file: 785777-92-6.mol

Synonyms:5-bromo-2-chloro-4-(trifluoromethyl)pyrimidine;785777-92-6;5-BROMO-2-CHLORO-4(TRIFLUOROMETHYL)PYRIMIDINE;5-Bromo-2-chloro-4-(trifluoromethyl)-1,3-diazine;MFCD13176600;Pyrimidine, 5-bromo-2-chloro-4-(trifluoromethyl)-;2-chloro-5-bromo-4-(trifluoromethyl)pyrimidine;SCHEMBL3186975;AMY2703;DTXSID50465509;AKOS016001644;AB66610;DS-3556;SY034607;CS-0208683;EN300-76396;A856603;Z1188084092

Chemical Property of 5-Bromo-2-chloro-4-(trifluoromethyl)pyrimidine

Chemical Property:

• PSA: 25.78000
• LogP: 2.91130
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 259.89637
• Heavy Atom Count: 12
• Complexity: 165

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-chloro-4-(trifluoromethyl)pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=NC(=N1)Cl)C(F)(F)F)Br

Technology Process of 5-Bromo-2-chloro-4-(trifluoromethyl)pyrimidine

There total 6 articles about 5-Bromo-2-chloro-4-(trifluoromethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-bromo-4-(trifluoromethyl)pyrimidin-2-ol (785777-90-4) → 5-bromo-2-chloro-4-(trifluoromethyl)pyrimidine (785777-92-6)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield: 89.0%

5-bromo-4-(trifluoromethyl)pyrimidin-2(1H)-one (785777-90-4) → 5-bromo-2-chloro-4-(trifluoromethyl)pyrimidine (785777-92-6)

Guidance literature:

With phosphorus trichloride; for 2h; Heating;

DOI:10.1002/ejoc.200400209

Reference yield: 49.0%

C4H8O*C12H24KO6(1+)*C7H18B3F3N3(1-) + 5-Bromo-2-chloropyrimidine (32779-36-5) → 5-bromo-2-chloro-4-(trifluoromethyl)pyrimidine (785777-92-6)

Guidance literature:

C₄H₈O*C₁₂H₂₄KO₆⁽¹⁺⁾*C₇H₁₈B₃F₃N₃^(1-); 5-Bromo-2-chloropyrimidine; In tetrahydrofuran; for 0.0833333h; Inert atmosphere;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; for 1h; Inert atmosphere;

DOI:10.1002/anie.201711316

upstream raw materials:

5-bromo-4-(trifluoromethyl)pyrimidin-2(1H)-one

4-(trifluoromethyl)pyrimidin-2(1H)-one

4-(trifluoromethyl)-2-pyrimidinol

5-bromo-4-(trifluoromethyl)pyrimidin-2-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 785777-92-6 5-BROMO-2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send