4-(2,2,2-Trifluoroethoxy)pyridin-2-amine

Base Information

• Chemical Name: 4-(2,2,2-Trifluoroethoxy)pyridin-2-amine
• CAS No.: 1379361-82-6
• Molecular Formula: C7H7F3N2O
• Molecular Weight: 192.14
• DSSTox Substance ID: DTXSID80577467
• Wikidata: Q82467491
• Mol file: 1379361-82-6.mol

Synonyms:4-(2,2,2-Trifluoroethoxy)pyridin-2-amine;1379361-82-6;2-Pyridinamine, 4-(2,2,2-trifluoroethoxy)-;SCHEMBL16054187;DTXSID80577467;XUPWSJQUWPOAOZ-UHFFFAOYSA-N;AS-0688;E80389;A904040;A1-38797

Chemical Property of 4-(2,2,2-Trifluoroethoxy)pyridin-2-amine

Chemical Property:

• PSA: 48.87000
• LogP: 1.53500
• Storage Temp.: 2-8°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 192.05104734
• Heavy Atom Count: 13
• Complexity: 162

Purity/Quality:

97% ^*data from raw suppliers

4-(2,2,2-Trifluoroethoxy)pyridin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=C1OCC(F)(F)F)N

Technology Process of 4-(2,2,2-Trifluoroethoxy)pyridin-2-amine

There total 4 articles about 4-(2,2,2-Trifluoroethoxy)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-trifluoroethyl trifluoromethanesulphonate (6226-25-1) + 2-amino-4-hydroxypyridine (33631-05-9) → 4-(2,2,2-trifluoroethoxy)pyridin-2-amine (1379361-82-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield:

tert-butyl N-[4-(2,2,2-trifluoroethoxy)-2-pyridyl]carbamate → 4-(2,2,2-trifluoroethoxy)pyridin-2-amine (1379361-82-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 2h;

Reference yield:

1,1,1-trifluoro-2-iodoethane (353-83-3) + 2-amino-4-hydroxypyridine (33631-05-9) → 4-(2,2,2-trifluoroethoxy)pyridin-2-amine (1379361-82-6)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 100 ℃; for 12h;

upstream raw materials:

2-amino-4-hydroxypyridine

1,1,1-trifluoro-2-iodoethane

2,2,2-trifluoroethyl trifluoromethanesulphonate

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