3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(8α,9S)-6'-Methoxycinchonan-9-yl]aMino]- 3-Cyclobutene-1,2-dione

Base Information

Chemical Name:3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(8α,9S)-6'-Methoxycinchonan-9-yl]aMino]- 3-Cyclobutene-1,2-dione
CAS No.:1256245-84-7
Molecular Formula:C32H28F6N4O3
Molecular Weight:630.59
Hs Code.:
Mol file:1256245-84-7.mol

Synonyms:3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(8α,9S)-6'-Methoxycinchonan-9-yl]aMino]- 3-Cyclobutene-1,2-dione

Suppliers and Price of 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(8α,9S)-6'-Methoxycinchonan-9-yl]aMino]- 3-Cyclobutene-1,2-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Strem Chemicals
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6'-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, 95%, (99% ee) (99% ee)
50mg
$ 137.00

ChemScene
3-[[3,5-Bis(trifluoroMethyl)phenyl]aMino]-4-[[(8a,9S)-6'-Methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione 99.41%
5g
$ 1239.00

ChemScene
3-[[3,5-Bis(trifluoroMethyl)phenyl]aMino]-4-[[(8a,9S)-6'-Methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione 99.41%
1g
$ 407.00

ChemScene
3-[[3,5-Bis(trifluoroMethyl)phenyl]aMino]-4-[[(8a,9S)-6'-Methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione 99.41%
100mg
$ 100.00

Ambeed
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6'-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione 97%99%ee
5g
$ 1520.00

Ambeed
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6'-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione 97%99%ee
100mg
$ 90.00

Ambeed
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6'-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione 97%99%ee
1g
$ 385.00

Ambeed
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6'-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione 97%99%ee
250mg
$ 150.00

Total 6 raw suppliers

Chemical Property of 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(8α,9S)-6'-Methoxycinchonan-9-yl]aMino]- 3-Cyclobutene-1,2-dione

Chemical Property:

Melting Point:227-228 °C (decomp)
Boiling Point:643.6±65.0 °C(Predicted)
PKA:9.24±0.70(Predicted)
PSA：83.56000
Density:1.44±0.1 g/cm3(Predicted)
LogP:6.68540
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6'-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, 95%, (99% ee) (99% ee) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(8α,9S)-6'-Methoxycinchonan-9-yl]aMino]- 3-Cyclobutene-1,2-dione

There total 2 articles about 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(8α,9S)-6'-Methoxycinchonan-9-yl]aMino]- 3-Cyclobutene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 9-epi-9-amino-9-deoxyquinine

: 1223105-85-8
3-(3,5-ditrifluoromethylphenylamino)-4-methoxybutane-3-en-1,2-dione

: 1256245-84-7
3-(3,5-bis-trifluoromethyl-phenylamino)-4-{[(S)-(6-methoxy-quinolin-4-yl)-((R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-amino}-cyclobut-3-ene-1,2-dione

Guidance literature:: In dichloromethane; at 20 ℃; for 48h;
DOI:10.1021/ol102294g

Reference yield:

: 130-95-0
quinine

: 1256245-84-7
3-(3,5-bis-trifluoromethyl-phenylamino)-4-{[(S)-(6-methoxy-quinolin-4-yl)-((R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-amino}-cyclobut-3-ene-1,2-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: methanol / 70 h / 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol;
DOI:10.1021/ol502148a