2,6-Dichloro-4-fluorobenzoic acid

Base Information

• Chemical Name: 2,6-Dichloro-4-fluorobenzoic acid
• CAS No.: 232275-55-7
• Molecular Formula: C7H3Cl2FO2
• Molecular Weight: 209.0019232
• Hs Code.: 2916399090
• Mol file: 232275-55-7.mol

Synonyms:2,6-Dichloro-4-fluorobenzoic acid

Chemical Property of 2,6-Dichloro-4-fluorobenzoic acid

Chemical Property:

• PSA: 37.30000
• LogP: 2.83070
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dichloro-4-fluorobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Dichloro-4-fluorobenzoic acid

There total 6 articles about 2,6-Dichloro-4-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

methyl 2,6-dichloro-4-fluorobenzoate (232275-56-8) → 2,6-dichloro-4-fluorobenzoic acid (232275-55-7)

Guidance literature:

With trimethylsilyl iodide; In tetrachloromethane; at 50 ℃; for 48h;

DOI:10.1016/S0968-0896(02)00021-4

Reference yield:

2,6-dichloro-4-nitrobenzoic acid (22509-50-8) → 2,6-dichloro-4-fluorobenzoic acid (232275-55-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: SOCl₂ / CH₂Cl₂ / 19 h / Heating

2.1: 10.8 g / 17 h / Heating

3.1: 78 percent / Na₂S₂O₄ / ethanol; H₂O / 2 h / Heating

4.1: NaNO₂; HCl / H₂O / 0.5 h / 0 - 5 °C

4.2: 48 percent / HBF₄ / H₂O / 0.5 h

5.1: 58 percent / TMSI / CCl₄ / 48 h / 50 °C

With hydrogenchloride; thionyl chloride; sodium dithionite; trimethylsilyl iodide; sodium nitrite; In tetrachloromethane; ethanol; dichloromethane; water;

DOI:10.1016/S0968-0896(02)00021-4

Reference yield:

methyl 2,6-dichloro-4-nitrobenzoate (232275-50-2) → 2,6-dichloro-4-fluorobenzoic acid (232275-55-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 78 percent / Na₂S₂O₄ / ethanol; H₂O / 2 h / Heating

2.1: NaNO₂; HCl / H₂O / 0.5 h / 0 - 5 °C

2.2: 48 percent / HBF₄ / H₂O / 0.5 h

3.1: 58 percent / TMSI / CCl₄ / 48 h / 50 °C

With hydrogenchloride; sodium dithionite; trimethylsilyl iodide; sodium nitrite; In tetrachloromethane; ethanol; water;

DOI:10.1016/S0968-0896(02)00021-4

upstream raw materials:

methyl 2,6-dichloro-4-fluorobenzoate

2,6-dichloro-4-nitrobenzoic acid

methyl 2,6-dichloro-4-nitrobenzoate

methyl 4-amino-2,6-dichlorobenzoate

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