Methyl 2,6-dichloro-4-aminobenzoate

Base Information

• Chemical Name: Methyl 2,6-dichloro-4-aminobenzoate
• CAS No.: 232275-49-9
• Molecular Formula: C8H7Cl2NO2
• Molecular Weight: 220.055
• Hs Code.: 2922499990
• Mol file: 232275-49-9.mol

Synonyms:3,5-dichloro-4-methoxy-aniline;3,5-dichloroanisidine;3.5-Dichlor-p-anisidin;3,5-Dichlor-4-methoxy-anilin;4-Amino-2,6-dichlorobenzoic acid methyl ester;Benzenamine,3,5-dichloro-4-methoxy;4-Amino-2,6-dichloroanisole;

Chemical Property of Methyl 2,6-dichloro-4-aminobenzoate

Chemical Property:

• Boiling Point: 367.9±37.0 °C(Predicted)
• PKA: 0.35±0.10(Predicted)
• PSA: 52.32000
• Density: 1.433
• LogP: 2.94340
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

4-Amino-2,6-dichloro-benzoicacidmethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2,6-dichloro-4-aminobenzoate

There total 14 articles about Methyl 2,6-dichloro-4-aminobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-tert-butoxycarbonylamino-2,6-dichloro-benzoic acid methyl ester (409127-35-1) → methyl 4-amino-2,6-dichlorobenzoate (232275-49-9)

Guidance literature:

With sulfuric acid; In ethyl acetate; at 20 ℃; for 2h;

Reference yield: 78.0%

methyl 2,6-dichloro-4-nitrobenzoate (232275-50-2) → methyl 4-amino-2,6-dichlorobenzoate (232275-49-9)

Guidance literature:

With sodium dithionite; In ethanol; water; for 2h; Heating;

DOI:10.1016/S0968-0896(02)00021-4

Reference yield: 69.0%

methyl 2,6-dichloro-4-((diphenylmethylene)amino)benzoate → methyl 4-amino-2,6-dichlorobenzoate (232275-49-9)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 25 ℃; for 3h;

DOI:10.1021/acs.jmedchem.5b01293

upstream raw materials:

methyl 2,6-dichloro-4-nitrobenzoate

2,6-dichloro-4-nitrobenzoic acid

2,6-dichloro-4-nitrobenzoyl chloride

4-tert-butoxycarbonylamino-2,6-dichloro-benzoic acid methyl ester

Downstream raw materials:

methyl 4-amino-2,6-dichloro-3-iodobenzoate

methyl 4-amino-2,6-dichloro-3-((trimethylsilyl)ethynyl)benzoate