2-(Benzyloxy)-5-methylbenzaldehyde

Base Information

• Chemical Name: 2-(Benzyloxy)-5-methylbenzaldehyde
• CAS No.: 53389-98-3
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID60361361
• Wikidata: Q82143665
• Mol file: 53389-98-3.mol

Synonyms:2-(benzyloxy)-5-methylbenzaldehyde;53389-98-3;5-Methyl-2-(phenylmethoxy)benzaldehyde;5-methyl-2-phenylmethoxybenzaldehyde;2-benzyloxy-5-methylbenzaldehyde;SCHEMBL8167293;DTXSID60361361;MFCD06625273;AKOS005291243;CS-0196346;E89995;A870734;SR-01000292891;SR-01000292891-1

Chemical Property of 2-(Benzyloxy)-5-methylbenzaldehyde

Chemical Property:

• PSA: 26.30000
• LogP: 3.38650
• Storage Temp.: 2-8°C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 226.099379685
• Heavy Atom Count: 17
• Complexity: 233

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-2-(phenylmethoxy)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)OCC2=CC=CC=C2)C=O

Technology Process of 2-(Benzyloxy)-5-methylbenzaldehyde

There total 10 articles about 2-(Benzyloxy)-5-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-hydroxy-5-methylbenzaldehyde (613-84-3) + benzyl bromide (100-39-0) → 2-(benzyloxy)-5-methylsalicylaldehyde (53389-98-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; Inert atmosphere;

DOI:10.1021/ol100316k

Reference yield: 100.0%

1-(benzyloxy)-2-bromo-4-methylbenzene (2830-53-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(benzyloxy)-5-methylsalicylaldehyde (53389-98-3)

Guidance literature:

1-(benzyloxy)-2-bromo-4-methylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12h; Further stages.;

DOI:10.1021/ol702879u

Reference yield: 77.0%

2-hydroxy-5-methylbenzaldehyde (613-84-3) + benzyl chloride (100-44-7) → 2-(benzyloxy)-5-methylsalicylaldehyde (53389-98-3)

Guidance literature:

With potassium carbonate; In ethanol; water; Inert atmosphere; Reflux;

DOI:10.1246/bcsj.81.1019

upstream raw materials:

2-hydroxy-5-methylbenzaldehyde

benzyl chloride

benzyl bromide

1-(benzyloxy)-2-bromo-4-methylbenzene

Downstream raw materials:

3-(2-benzyloxy-5-methyl-phenyl)-3-hydroxy-propionic acid

6-Methyl-2-phenylbenzofuran

1-(benzyloxy)-2-(cyclopropylidenemethyl)-4-methylbenzene

methyl 3-(2-benzyloxy-5-methyl)phenyl-3-hydoxy-2-methylenepropanoate

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