3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE

Base Information

• Chemical Name: 3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
• CAS No.: 81971-38-2
• Molecular Formula: C6H6BrNO
• Molecular Weight: 188.024
• Hs Code.: 2933399090
• Mol file: 81971-38-2.mol

Synonyms:3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE;3-bromo-1-methyl-1,2-dihydropyridin-2-one;3-Bromo-1-methyl-1H-pyridin-2-one

Chemical Property of 3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE

Chemical Property:

• Boiling Point: 120-125 °C(Press: 0.5 Torr)
• PKA: -2.77±0.62(Predicted)
• PSA: 22.00000
• Density: 1.664±0.06 g/cm3(Predicted)
• LogP: 1.14780
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromo-1-methylpyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE

There total 8 articles about 3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-bromopyridin-2(1H)-one (13466-43-8) + methyl iodide (74-88-4) → 3-bromo-1-methyl-1H-pyridin-2-one (81971-38-2)

Guidance literature:

3-bromopyridin-2(1H)-one; With potassium-t-butoxide; In 1,4-dioxane; at 100 ℃; for 2h; Schlenk technique; Inert atmosphere;

iodomethane; In 1,4-dioxane; at 80 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0034-1378703

Reference yield: 92.0%

3-bromo-pyridin-2-ol (13466-43-8) + methyl iodide (74-88-4) → 3-bromo-1-methyl-1H-pyridin-2-one (81971-38-2)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In toluene; at 40 ℃; for 15h;

Reference yield: 85.0%

3-bromopyridin-2(1H)-one (13466-43-8) + dimethyl sulfate (77-78-1) → 3-bromo-1-methyl-1H-pyridin-2-one (81971-38-2)

Guidance literature:

With sodium methylate; In methanol; at 50 - 60 ℃; for 3h;

DOI:10.1021/ja00379a016

upstream raw materials:

3-Bromopyridine

methyl iodide

1-methyl-2-pyridone

3-bromopyridin-2(1H)-one

Downstream raw materials:

3-(3-benzylsulfanyl-2-ethyl-phenyl)-1-methyl-1H-pyridin-2-one

3-(3-benzylsulfanyl-2-methoxy-phenyl)-1-methyl-1H-pyridin-2-one

1-methyl-3-phenyl-piperidin-2-one

2-chloro-5-(1-methyl-2-oxo-1,2-dihydro-pyridin-3-ylamino)-benzoic acid methyl ester

Refernces

• 1、 -. "COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES". Paragraph 0854. . Retrieved 2021/02/26.
• 2、 -. "HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS". Paragraph 0672; 0675; 0676. . Retrieved 2019/02/05.