methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate

Base Information

• Chemical Name: methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate
• CAS No.: 890839-11-9
• Molecular Formula: C16H23BO4
• Molecular Weight: 290.167
• Mol file: 890839-11-9.mol

Synonyms:methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate

Chemical Property of methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate

Chemical Property:

• PSA: 44.76000
• LogP: 2.26230

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate

There total 14 articles about methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 2-(4-bromophenyl)propanoate (83636-46-8) + bis(pinacol)diborane (73183-34-3) → methyl 2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan -2-yl)phenyl]propionate (890839-11-9)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; for 6h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2019.01.003

Reference yield: 70.0%

methyl iodide (74-88-4) → methyl 2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan -2-yl)phenyl]propionate (890839-11-9)

Guidance literature:

methyl [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield: 60.0%

Methyl 2-<(methoxallyl)oxy>acetate + 2-(4-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (73852-88-7) → methyl 2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan -2-yl)phenyl]propionate (890839-11-9)

Guidance literature:

With pyridine; nickel(II) iodide; 4,5-dihydro-2-(pyridin-2-yl)-1H-imidazole; magnesium chloride; zinc; In N,N-dimethyl acetamide; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00174

upstream raw materials:

methyl iodide

methyl 2-(4-bromophenyl)propanoate

bis(pinacol)diborane

methyl (4-nitrophenyl)acetate

Downstream raw materials:

2-(6-chloro-carbazol-2-yl)-propionic acid

methyl 2-{4-[2-methyl-3-(phenylthio)-1H-5-indolyl]phenyl}propanoate