(R)-Ethyl 2-(piperidin-3-yl)acetic acid hydrochloride

Base Information

• Chemical Name: (R)-Ethyl 2-(piperidin-3-yl)acetic acid hydrochloride
• CAS No.: 1233200-48-0
• Molecular Formula: C9H17NO2 HCl
• Molecular Weight: 207.7
• Mol file: 1233200-48-0.mol

Synonyms:(R)-3-Piperidine acetate ethyl ester hydrochloride;(R)-3-Piperidine acetic acid ethyl ester hydrochloride;(R)-Ethyl 2-(piperidin-3-yl)acetate hydrochloride;(R)-Ethyl 2-(piperidin-3-yl)acetic acid hydrochloride;(R)-ETHYL 3-PIPERIDINYLACETATE HCL;ethyl (R)-piperidine-3-acetatehydrochloride;(R)-Piperidin-3-yl-acetic acid ethyl ester hydrochloride;(R)-ethyl 2-(piperidin-3-yl)acetate

Chemical Property of (R)-Ethyl 2-(piperidin-3-yl)acetic acid hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 2.07000
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(R)-Ethyl2-(Piperidin-3-yl)acetateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-Ethyl 2-(piperidin-3-yl)acetic acid hydrochloride

There total 5 articles about (R)-Ethyl 2-(piperidin-3-yl)acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl (3R)-piperidin-3-ylacetate (188883-57-0) → (R)-piperidin-3-yl-acetic acid ethyl ester hydrochloride (1233200-48-0,16780-05-5)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 ℃; for 2h;

DOI:10.1080/00397911.2010.536293

Reference yield:

pyridin-3-yl-acetic acid ethyl ester (39931-77-6) → (R)-piperidin-3-yl-acetic acid ethyl ester hydrochloride (1233200-48-0,16780-05-5)

Guidance literature:

Multi-step reaction with 4 steps

1: acetonitrile / 12 h / Reflux

2: 5%-palladium/activated carbon; hydrogen / ethanol / 8 h / 20 °C / 7500.75 Torr

3: (S)-Mandelic acid / ethyl acetate / 4 h / Reflux; Resolution of racemate

4: hydrogenchloride / diethyl ether / 2 h / 0 °C

With hydrogenchloride; 5%-palladium/activated carbon; (S)-Mandelic acid; hydrogen; In diethyl ether; ethanol; ethyl acetate; acetonitrile;

DOI:10.1080/00397911.2010.536293

Reference yield:

1-benzyl-3-ethoxycarbonylmethyl-pyridinium chloride (1232140-16-7) → (R)-piperidin-3-yl-acetic acid ethyl ester hydrochloride (1233200-48-0,16780-05-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 5%-palladium/activated carbon; hydrogen / ethanol / 8 h / 20 °C / 7500.75 Torr

2: (S)-Mandelic acid / ethyl acetate / 4 h / Reflux; Resolution of racemate

3: hydrogenchloride / diethyl ether / 2 h / 0 °C

With hydrogenchloride; 5%-palladium/activated carbon; (S)-Mandelic acid; hydrogen; In diethyl ether; ethanol; ethyl acetate;

DOI:10.1080/00397911.2010.536293

upstream raw materials:

pyridin-3-yl-acetic acid ethyl ester

1-benzyl-3-ethoxycarbonylmethyl-pyridinium chloride

ethyl (3R)-piperidin-3-ylacetate

3-(2-ethoxy-2-oxoethyl)pyridin-1-ium-1-olate

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