3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate

Base Information

Chemical Name:3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate
CAS No.:1357160-72-5
Molecular Formula:C20H22N2O4
Molecular Weight:354.406
Hs Code.:
DSSTox Substance ID:DTXSID801018151
Nikkaji Number:J2.884.534K
ChEMBL ID:CHEMBL2402927
Mol file:1357160-72-5.mol

Synonyms:URB937

Suppliers and Price of 3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
URB937
5mg
$ 45.00

Sigma-Aldrich
URB937 ≥95% (HPLC)
5mg
$ 79.80

Sigma-Aldrich
URB937 ≥95% (HPLC)
25mg
$ 309.00

Medical Isotopes, Inc.
URB937
100 mg
$ 1225.00

Matrix Scientific
3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate 95%
100mg
$ 722.00

Matrix Scientific
3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate 95%
250mg
$ 1804.00

DC Chemicals
URB-937
003
$ 1950.00

ChemScene
URB937 99.86%
10mg
$ 170.00

ChemScene
URB937 99.86%
5mg
$ 100.00

ChemScene
URB937 99.86%
50mg
$ 510.00

Total 12 raw suppliers

Chemical Property of 3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate

Chemical Property:

Boiling Point:562.8±50.0 °C(Predicted)
PKA:9.08±0.50(Predicted)
PSA：101.65000
Density:1.31±0.1 g/cm3(Predicted)
LogP:4.67040
Storage Temp.:?20°C
Solubility.:DMSO: soluble15mg/mL, clear
XLogP3:3.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:354.15795719
Heavy Atom Count:26
Complexity:492

Purity/Quality:

99%, ^*data from raw suppliers

URB937 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)NC(=O)OC2=CC(=C(C=C2)O)C3=CC(=CC=C3)C(=O)N
Uses URB 937 is a potent inhibitor of fatty-acid amide hydrolase (FAAH), an intracellular serine hydrolase responsible for the deactivation of the endocannabinoid anandamide. It is actively extruded from t he central nervous system (CNS), and therefore increases anandamide levels exclusively in peripheral tissues. URB 937 is a potent inhibitor of fatty-acid amide hydrolase (FAAH), an intracellular serine hydrolase responsible for the deactivation of the endocannabinoid anandamide. It is actively extruded from the central nervous system (CNS), and therefore increases anandamide levels exclusively in peripheral tissues.

Technology Process of 3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate

There total 7 articles about 3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1357091-70-3
[4-benzyloxy-3-(3-carbamoylphenyl)phenyl]-N-cyclohexylcarbamate

: 1357160-72-5
URB₉₃₇

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; at 50 ℃; for 4h; under 3040.2 Torr;

Reference yield:

: 252578-40-8
4-(benzyloxy)-3-bromophenol

: 1357160-72-5
URB₉₃₇

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 2 h / Reflux

2: triethylamine / toluene; acetonitrile / 18 h / Reflux

3: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 4 h / 50 °C / 3040.2 Torr

With hydrogen; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In ethanol; water; ethyl acetate; toluene; acetonitrile; 1: Suzuki Coupling;

Reference yield:

: 2973-78-6
3-bromo-4-hydroxybenzylaldehyde

: 1357160-72-5
URB₉₃₇

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 72 h / 40 °C

3: sodium methylate / ethanol / 1 h / 20 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 2 h / Reflux

5: triethylamine / toluene; acetonitrile / 18 h / Reflux

6: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 4 h / 50 °C / 3040.2 Torr

With hydrogen; sodium methylate; sodium carbonate; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; 4: Suzuki Coupling;