4-(p-Tolyl)-1,8-naphthyridin-2(1H)-one

Base Information

Chemical Name:4-(p-Tolyl)-1,8-naphthyridin-2(1H)-one
CAS No.:127446-47-3
Molecular Formula:C15H12N2O
Molecular Weight:236.26858
Hs Code.:2933990090
DSSTox Substance ID:DTXSID40563220
Nikkaji Number:J329.297E
Wikidata:Q82447597
Mol file:127446-47-3.mol

Synonyms:4-(p-Tolyl)-1,8-naphthyridin-2(1H)-one;127446-47-3;4-(4-methylphenyl)-1H-1,8-naphthyridin-2-one;4-(4-Methylphenyl)-1,8-naphthyridin-2(1H)-one;DTXSID40563220

Suppliers and Price of 4-(p-Tolyl)-1,8-naphthyridin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-(p-Tolyl)-1,8-naphthyridin-2(1H)-one 95+%
1g
$ 772.00

American Custom Chemicals Corporation
4-(PARA-TOLYL)-1,8-NAPHTHYRIDIN-2(1H)-ONE 95.00%
5MG
$ 503.45

Alichem
4-(p-Tolyl)-1,8-naphthyridin-2(1H)-one
1g
$ 615.44

Total 3 raw suppliers

Chemical Property of 4-(p-Tolyl)-1,8-naphthyridin-2(1H)-one

Chemical Property:

PSA：46.01000
LogP:3.31080
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:236.094963011
Heavy Atom Count:18
Complexity:356

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

4-(p-Tolyl)-1,8-naphthyridin-2(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=CC(=O)NC3=C2C=CC=N3

Technology Process of 4-(p-Tolyl)-1,8-naphthyridin-2(1H)-one

There total 4 articles about 4-(p-Tolyl)-1,8-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 127446-46-2
2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester

: 127446-47-3
4-(4-Methylphenyl)-1,8-naphthyridin-2-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 72h; Heating;
DOI:10.1021/jo00302a049

Reference yield:

: 86847-59-8
2-(pivaloylamino)pyridine

: 127446-47-3
4-(4-Methylphenyl)-1,8-naphthyridin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1) n-butyllithium / 1) THF, 0 deg C, 3 h; 2) THF, room temp., 2 h

2: 73 percent / tetrahydrofuran / -78 - 20 °C

3: 84 percent / 3N-aq. HCl / dioxane / 72 h / Heating

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jo00302a049

Reference yield:

: 122334-36-5
N-methoxy-N,4-dimethylbenzamide

: 127446-47-3
4-(4-Methylphenyl)-1,8-naphthyridin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1) n-butyllithium / 1) THF, 0 deg C, 3 h; 2) THF, room temp., 2 h

2: 73 percent / tetrahydrofuran / -78 - 20 °C

3: 84 percent / 3N-aq. HCl / dioxane / 72 h / Heating

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jo00302a049