86847-59-8

Basic information

• Product Name: 2,2-DIMETHYL-N-PYRIDIN-2-YL-PROPIONAMIDE
• Synonyms: PROPANAMIDE, 2,2-DIMETHYL-N-2-PYRIDINYL-;2-(PIVALOYLAMINO)PYRIDINE;2,2-DIMETHYL-N-(2-PYRIDINYL)PROPANAMIDE;2,2-DIMETHYL-N-PYRIDIN-2-YL-PROPIONAMIDE;2-(Pivaloylamino)pyridine 2,2-dimethyl-N-(2-pyridinyl)propanamide ;2-Pivalamidopyridine;N-Boc-2-aMinopyridine;2,2-diMethyl-N-(pyridin-2-yl)propanaMide
• CAS NO: 86847-59-8
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.23
• Product Categories: Heterocyclic Compounds;C9 to C46;Heterocyclic Building Blocks;Pyridines;Aromatics;Heterocycles;Miscellaneous Reagents;Piperazines ,Oxazolines/Oxazolidines
• Mol File: 86847-59-8.mol
• Article Data: 45

Chemical Properties

• Melting Point: 71-75 °C(lit.)
• Boiling Point: 349.3oC at 760 mmHg
• Flash Point: 165.1oC
• Appearance: /Solid
• Density: 1.078g/cm3
• Vapor Pressure: 4.73E-05mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• PKA: 13.82±0.70(Predicted)
• CAS DataBase Reference: 2,2-DIMETHYL-N-PYRIDIN-2-YL-PROPIONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYL-N-PYRIDIN-2-YL-PROPIONAMIDE(86847-59-8)
• EPA Substance Registry System: 2,2-DIMETHYL-N-PYRIDIN-2-YL-PROPIONAMIDE(86847-59-8)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 86847-59-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

2-Pivalamidopyridine (cas# 86847-59-8) is a compound useful in organic synthesis.

InChI:InChI=1/C10H14N2O/c1-10(2,3)9(13)12-8-6-4-5-7-11-8/h4-7H,1-3H3,(H,11,12,13)

Upstream product

• 590-28-3 potassium cyanate 
• 630-18-2 tert-butyl isocyanide 
• 107264-09-5 1-fluoro-pyridinium tetrafluoroborate 
• 504-29-0 2-aminopyridine 
• 24331-71-3 N,N-dimethylpivalamide 
• 5231-96-9 N-(2-pyridyl)acetamide 
• 754-10-9 2,2-dimethylpropionamide 
• 57785-86-1 pyridin-2-yl tosylate 
• 109-09-1 2-chloropyridine 
• 111098-28-3 (1-Benzotriazol-1-yl-2,2-dimethyl-propyl)-pyridin-2-yl-amine 
• 3282-30-2 pivaloyl chloride 
• 4589-12-2 N-(pyrid-2-yl)benzamide 
• 5223-01-8 2-phenyl-N-(pyridin-2-yl)acetamide 
• 96354-74-4 N-(diphenylmethyl)pyridin-2-amine 

Downstream Products

• 125867-32-5 phenyl (2-pivaloylamino-3-pyridyl) ketone 
• 254-60-4 1,8-naphthyridine 
• 86847-64-5 N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide 
• 882029-13-2 C₁₅H₂₀N₂O₃ 
• 239099-70-8 1-butyl-3-ethoxycarbonyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine 
• 185540-13-0 1-pentyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylic acid 
• 185540-07-2 1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylic acid 
• 185540-09-4 1-isopropyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylic acid 
• 185540-04-9 ethyl 1-methyl-4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylate 
• 185540-03-8 ethyl 4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylate 
• 185540-12-9 1-methyl-4-(2-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylic acid 

Relevant articles and documents

Copper- or Nickel-Enabled Oxidative Cross-Coupling of Unreactive C(sp3)-H Bonds with Azole C(sp2)-H Bonds: Rapid Access to β-Azolyl Propanoic Acid Derivatives

β-Azolyl propanoic acid derivatives are frequently found in biologically active molecules and pharmaceuticals. Here, we report the oxidative heteroarylation of unactivated C(sp3)-H bonds with azole C(sp2)-H bonds via copper or nickel catalysis with the aid of removable bidentate auxiliary, which provides a rapid pathway to β-azolyl propanoic acid derivatives. A variety of azoles such as oxazole, benzoxazole, thiazole, benzothiazoles, benzimidazole, purine, and even [1,2,4]triazolo[1,5-a]pyrimidine could be engaged in this protocol.

6H-THIENO[2,3-E][1,2,4]TRIAZOLO[3,4-C][1,2,4]TRIAZEPINE DERIVATIVE

The 6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivatives or salts thereof of the present invention have BRD4 inhibitory activity, and thus, they are useful as medicaments, in particular, as prophylaxis and/or therapeutic agents for diseases associated with BRD4.

Synthesis method of N-heterocyclic acylamide derivative

The invention discloses a synthesis method of an N-heterocyclic acylamide derivative. A reaction general formula is as shown in the specification. According to the synthesis method, an imidazo heterocyclic amine compound I is taken as a raw material; unde