Benzoic acid, 3-aMino-5-chloro-2-Methyl-, Methyl ester

Base Information

• Chemical Name: Benzoic acid, 3-aMino-5-chloro-2-Methyl-, Methyl ester
• CAS No.: 294190-18-4
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.637
• Hs Code.: 2922499990
• Mol file: 294190-18-4.mol

Synonyms:Benzoic acid, 3-aMino-5-chloro-2-Methyl-, Methyl ester;Methyl 3-amino-5-chloro-2-methylbenzoate

Chemical Property of Benzoic acid, 3-aMino-5-chloro-2-Methyl-, Methyl ester

Chemical Property:

• PSA: 52.32000
• LogP: 2.59840
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-Amino-5-chloro-2-methylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 3-aMino-5-chloro-2-Methyl-, Methyl ester

There total 3 articles about Benzoic acid, 3-aMino-5-chloro-2-Methyl-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 5-chloro-2-methyl-3-nitrobenzoate (294190-17-3) → methyl 3-amino-5-chloro-2-methylbenzoate (294190-18-4)

Guidance literature:

With stannous chloride dihydrate; In ethyl acetate; for 3h; Reflux;

Reference yield:

5-chloro-2-methylbenzoic acid (7499-06-1) → methyl 3-amino-5-chloro-2-methylbenzoate (294190-18-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 0.17 h / -10 °C

1.2: 0.5 h / -10 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3.1: water; ammonium chloride; iron / ethanol / 1 h / 80 °C

With sulfuric acid; water; iron; sodium carbonate; ammonium chloride; In ethanol; N,N-dimethyl-formamide;

Reference yield:

5-chloro-2-methyl-3-nitrobenzoic acid (154257-81-5) → methyl 3-amino-5-chloro-2-methylbenzoate (294190-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

2: water; ammonium chloride; iron / ethanol / 1 h / 80 °C

With water; iron; sodium carbonate; ammonium chloride; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

5-chloro-2-methylbenzoic acid

5-chloro-2-methyl-3-nitrobenzoic acid

methyl 5-chloro-2-methyl-3-nitrobenzoate

Downstream raw materials:

methyl 3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)amino)-5-chloro-2-methylbenzoate

methyl 3-(((cis)-4-((tert-butoxycarbonyl)amino)cyclohexyl)amino)-5-chloro-2-methylbenzoate

methyl 5-chloro-3-(cyclobutylamino)-2-methylbenzoate

methyl 5-chloro-2-methyl-3-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzoate

Refernces

• 1、 -. "ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS". . . Retrieved 2013/12/03.