6-Bromo-8-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 6-Bromo-8-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester
• CAS No.: 907945-82-8
• Molecular Formula: C11H11BrN2O2
• Molecular Weight: 283.125
• Mol file: 907945-82-8.mol

Synonyms:6-Bromo-8-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

Chemical Property of 6-Bromo-8-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

Chemical Property:

• PSA: 43.60000
• LogP: 2.58190

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl6-bromo-8-methylimidazo[1,2-a]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-8-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

There total 1 articles about 6-Bromo-8-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.5%

ethyl Bromopyruvate (70-23-5) + 5-bromo-3-methyl-pyridin-2-ylamine (3430-21-5) → ethyl 6-bromo-8-methylimidazo[1,2-a]pyridine-2-carboxylate (907945-82-8)

Guidance literature:

In ethanol; at 90 ℃; for 16h;

Reference yield:

ethyl 6-bromo-8-methylimidazo[1,2-a]pyridine-2-carboxylate (907945-82-8) + 4-Chlorophenylboronic acid (1679-18-1) → ethyl 6-(4-chlorophenyl)-8-methylimidazo[1,2-a]pyridine-2-carboxylate (907945-83-9)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 16h;

upstream raw materials:

ethyl Bromopyruvate

5-bromo-3-methyl-pyridin-2-ylamine

Downstream raw materials:

ethyl 6-(4-chlorophenyl)-8-methylimidazo[1,2-a]pyridine-2-carboxylate

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