Carbamic acid, [(1R)-1-acetyl-2-methylpropyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [(1R)-1-acetyl-2-methylpropyl]-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 327600-47-5
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.293
• Mol file: 327600-47-5.mol

Synonyms:Carbamic acid, [(1R)-1-acetyl-2-methylpropyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Carbamic acid, [(1R)-1-acetyl-2-methylpropyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(1R)-1-acetyl-2-methylpropyl]-, 1,1-dimethylethyl ester (9CI)

There total 5 articles about Carbamic acid, [(1R)-1-acetyl-2-methylpropyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

methylmagnesium bromide (75-16-1) + tert-butyl (S)-(3-methyl-1-morpholino-1-oxobutan- 2-yl)carbamate → (3S)-3-N-(tert-butyloxycarbonyl)amino-4-methylpentan-2-one (128211-52-9,327600-47-5)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol200323r

Reference yield: 11.0%

methylmagnesium bromide (75-16-1) + N-tert-butoxycarbonyl-L-valine methyl ester (58561-04-9) → tert-butyl (S)-(2-hydroxy-2,4-dimethylpentan-3-yl)carbamate (157035-77-3) + (3S)-3-N-(tert-butyloxycarbonyl)amino-4-methylpentan-2-one (128211-52-9,327600-47-5)

Guidance literature:

In tetrahydrofuran; 1.) 0 deg C, 2.) r.t., 20 h;

DOI:10.1021/jo00095a052

Reference yield: 2.0%

methylmagnesium bromide (75-16-1) + N-tert-butoxycarbonyl-L-valine methyl ester (58561-04-9) → tert-butyl (S)-(2-hydroxy-2,4-dimethylpentan-3-yl)carbamate (157035-77-3) + (RS)-N-(t-Butylcarboxy)-3-amino-4-methylpentan-2-one (327600-47-5)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 36h; Ambient temperature;

DOI:10.1055/s-1998-1700

upstream raw materials:

methylmagnesium bromide

N-tert-butoxycarbonyl-L-valine methyl ester

t-Boc-L-valine

Downstream raw materials:

tert-butyl (S)-4-methyl-2-oxopentan-3-ylcarbamate

C₁₃H₂₀N₂O*ClH

(R)-(1-carbamoyl-2-methyl-propyl)-carbamicacidtert-butyl ester

Boc-Val-NH₂