AZ-5104

Base Information

Chemical Name:AZ-5104
CAS No.:1421373-98-9
Molecular Formula:C27H31N7O2
Molecular Weight:485.589
Hs Code.:
Mol file:1421373-98-9.mol

Synonyms:AZ5104;AZ-5104;N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;N-[2-[[2-(Dimethylamino)ethyl]methylamino]-5-[[4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-4-methoxyphenyl]-2-propenamide;AZ7550

Suppliers and Price of AZ-5104

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AZ5104
1mg
$ 55.00

DC Chemicals
AZ5104 >98%
100 mg
$ 400.00

DC Chemicals
AZ5104 >98%
250 mg
$ 800.00

Crysdot
AZ5104 98+%
250mg
$ 666.00

Crysdot
AZ5104 98+%
100mg
$ 534.00

Crysdot
AZ5104 98+%
50mg
$ 329.00

ChemScene
AZ-5104 99.92%
50mg
$ 275.00

ChemScene
AZ-5104 99.92%
10mg
$ 80.00

ChemScene
AZ-5104 99.92%
5mg
$ 55.00

ChemScene
AZ-5104 99.92%
200mg
$ 550.00

Total 29 raw suppliers

Chemical Property of AZ-5104

Chemical Property:

Appearance/Colour:Solid powder
PKA:12.68±0.70(Predicted)
PSA：98.41000
Density:1.267±0.06 g/cm3(Predicted)
LogP:4.64540
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

AZ5104 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses AZ7550 is an impurity of the drug Osimertinib (A808075). Osimertinib is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).

Technology Process of AZ-5104

There total 11 articles about AZ-5104 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

: N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)-3-chloropropaneamide

: 1421373-98-9
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide

Guidance literature:: With triethylamine; In acetonitrile; at 80 ℃;

Reference yield:

: tert-butyl 3-(2-((5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)amino)pyrimidin-4-yl)-1H-indole-1-carboxylate

: 1421373-98-9
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 1421372-34-0
N- (4-fluoro-2-methoxy-5-nitrophenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine

: 1421373-98-9
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.5 h / 140 °C / Microwave irradiation

2: iron; ammonium chloride / water; ethanol / 3 h / 105 °C

3: dichloromethane / 1 h / -5 °C

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl acetamide; water;