Technology Process of 1-[1-(4-Fluoro-phenyl)-ethyl]-piperazine
There total 4 articles about 1-[1-(4-Fluoro-phenyl)-ethyl]-piperazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
methanol; isopropyl alcohol;
at 4 - 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: phosphorus tribromide / dichloromethane / 4 h / 4 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
3: hydrogenchloride / isopropyl alcohol; methanol / 12 h / 4 - 20 °C
With
hydrogenchloride; phosphorus tribromide; potassium carbonate;
In
methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: aluminum (III) chloride / 2 h / 4 °C
2: sodium tetrahydroborate; methanol / 1.25 h / 4 °C
3: phosphorus tribromide / dichloromethane / 4 h / 4 - 20 °C
4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
5: hydrogenchloride / isopropyl alcohol; methanol / 12 h / 4 - 20 °C
With
hydrogenchloride; methanol; aluminum (III) chloride; sodium tetrahydroborate; phosphorus tribromide; potassium carbonate;
In
methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
