403-41-8

Basic information

• Product Name: 1-(4-Fluorophenyl)ethanol
• Synonyms: 4-fluoro-α-methylbenzyl alcohol;4-Fluoro-alpha-methylbenzyl alcohol 97%;4-Fluoro-alpha-methylbenzylalcohol97%;1-(p-Fluorophenyl)ethyl alcohol;4-Fluoro-α-methylbenzenemethanol;α-Methyl-4-fluorobenzenemethanol;α-Methyl-4-fluorobenzyl alcohol;4-Fluoro-alpha-methylbenzyl alcohol,99%
• CAS NO: 403-41-8
• Molecular Formula: C₈H₉FO
• Molecular Weight: 140.15
• EINECS: 206-959-3
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Fluorine Compounds;Phenols;Alcohols;C7 to C8;Oxygen Compounds;Fluorine series
• Mol File: 403-41-8.mol
• Article Data: 507

Chemical Properties

• Melting Point: 9 °C
• Boiling Point: 90-92 °C7 mm Hg(lit.)
• Flash Point: 195 °F
• Appearance: clear light yellow liquid
• Density: 1.109 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0829mmHg at 25°C
• Refractive Index: n20/D 1.501(lit.)
• Storage Temp.: 2-8°C
• PKA: 14.36±0.20(Predicted)
• CAS DataBase Reference: 1-(4-Fluorophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenyl)ethanol(403-41-8)
• EPA Substance Registry System: 1-(4-Fluorophenyl)ethanol(403-41-8)

Safety Data

• Hazard Codes: Xi,F,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 403-41-8(Hazardous Substances Data)

Usage

Chemical Properties

clear light yellow liquid

General Description

4-Fluoro-α-methylbenzyl alcohol was isolated as phytocomponent in the methanolic extracts of the whole plant of Thevetia peruviana.

InChI:InChI=1/C8H9FO/c1-6(10)7-2-4-8(9)5-3-7/h2-6,10H,1H3

Upstream product

• 67-56-1 methanol 
• 75-89-8 2,2,2-trifluoroethanol 
• 456-16-6 1-(1-chloroethyl)-4-fluorobenzene 
• 107-03-9 1-thiopropane 
• 64-17-5 ethanol 
• 598-38-9 2,2-dicloroethanol 
• 127-09-3 sodium acetate 
• 107-19-7 propargyl alcohol 
• 64-19-7 acetic acid 
• 65130-46-3 1-(4-fluorophenyl)ethyl bromide 
• 405-99-2 para-fluorostyrene 
• 459-47-2 1-ethyl-4-fluorobenzene 
• 1023815-13-5 1-(4-fluorophenyl)-2-phenoxyethan-1-ol 
• 248255-98-3 1-(4-fluorophenyl)-2-phenoxyethan-1-one 

Downstream Products

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 456-16-6 1-(1-chloroethyl)-4-fluorobenzene 
• 2063-74-3 4,4'-(1,1'-oxybis(ethane-1,1-diyl))bis(fluorobenzene) 
• 65130-46-3 1-(4-fluorophenyl)ethyl bromide 
• 111662-72-7 1-(4-fluorophenyl)ethyl methyl ether 
• 111662-74-9 1-(4-fluorophenyl)ethyl ethyl ether 
• 403-41-8 (S)-1-(4-fluorophenyl)ethan-1-ol 
• 172585-57-8 (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester 
• 403-41-8 (R)-1-(4-fluorophenyl)ethan-1-ol 
• 323-91-1 2-(4-fluoro-phenyl)-quinoline 
• 2928-12-3 rac-1-(4-fluorophenyl)ethyl acetate 
• 771-63-1 2,3,5,6-tetrafluoro-1,4-benzenediol 

Relevant articles and documents

N-Propylphthalimide-Substituted Silver(I) N-Heterocyclic Carbene Complexes and Ruthenium(II) N-Heterocyclic Carbene Complexes: Synthesis and Transfer Hydrogenation of Ketones

This study deals with the synthesis of N-propylphthalimide substituted Ag(I)-N-heterocyclic carbene (NHC) complexes and N-propylphthalimide substituted Ru(II)-NHC complexes in the transfer hydrogenation of ketones. The Ag(I)-NHC complexes were synthesized

Ru(ii)-N-heterocyclic carbene complexes: Synthesis, characterization, transfer hydrogenation reactions and biological determination

A series of ruthenium(ii) complexes with N-heterocyclic carbene ligands were successfully synthesized by transmetalation reactions between silver(i) N-heterocyclic carbene complexes and [RuCl2(p-cymene)]2 in dichloromethane under Ar

Nickel-Catalyzed Enantioselective Hydroboration of Vinylarenes

The enantioselective hydroboration of vinylarenes catalyzed by a chiral, nonracemic nickel catalyst is presented as a facile method for generating chiral benzylic boronate esters. Various vinylarenes react with bis(pinacolato)diboron (B2pin2) in the presence of MeOH as a hydride source to form chiral boronate esters in up to 92% yield with up to 94% ee. The use of anhydrous Me4NF to activate B2pin2 is crucial for ensuring fast transmetalation to achieve high enantioselectivities.

Manganese-Catalyzed Hydrogenation of Ketones under Mild and Base-free Conditions

In this paper, several Mn(I) complexes were applied as catalysts for the homogeneous hydrogenation of ketones. The most active precatalyst is the bench-stable alkyl bisphosphine Mn(I) complex fac-[Mn(dippe) (CO)3(CH2CH2CH3)]. The reaction proceeds at room temperature under base-free conditions with a catalyst loading of 3 mol % and a hydrogen pressure of 10 bar. A temperature-dependent selectivity for the reduction of α,β-unsaturated carbonyls was observed. At room temperature, the carbonyl group was selectively hydrogenated, while the C=C bond stayed intact. At 60 °C, fully saturated systems were obtained. A plausible mechanism based on DFT calculations which involves an inner-sphere hydride transfer is proposed.