rac N-DideMethyl Dapoxetine

Base Information

• Chemical Name: rac N-DideMethyl Dapoxetine
• CAS No.: 119357-34-5
• Molecular Formula: C19H19NO
• Molecular Weight: 277.366
• Mol file: 119357-34-5.mol

Synonyms:rac N-DideMethyl Dapoxetine;α-[2-(1-Naphthalenyloxy)ethyl]benzeneMethanaMine;alpha-[2-(1-Naphthalenyloxy)ethyl]benzenemethanamine

Chemical Property of rac N-DideMethyl Dapoxetine

Chemical Property:

• PSA: 35.25000
• LogP: 5.00900
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform, Ethyl Acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

racN-DidemethylDapoxetine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The racemic metabolite of Dapoxetine (D185700). Selective serotonin reuptake inhibitor antidepressant.

Technology Process of rac N-DideMethyl Dapoxetine

There total 9 articles about rac N-DideMethyl Dapoxetine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H23NO2 → 1-phenyl-3-(naphthyl-1-oxy)propylamine (119357-34-5)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c9nj03217g

Reference yield:

N-1-phenyl-3-(naphthyl-1-oxo)propylbenzamide → 1-phenyl-3-(naphthyl-1-oxy)propylamine (119357-34-5)

Guidance literature:

With acetic acid; at 120 ℃; for 2h;

Reference yield:

(R)-1-phenyl-3-(naphthyl-1-oxy)propylamine tartrate → 1-phenyl-3-(naphthyl-1-oxy)propylamine (119357-34-5)

Guidance literature:

With salicylaldehyde; acetic acid; at 90 ℃; for 2.5h; Reagent/catalyst; Temperature;

upstream raw materials:

3-Amino-3-phenylpropionic acid

benzaldehyde

3-amino-3-phenyl-1-propanol

3-(naphthalen-1-yloxy)-1-phenylpropan-1-one

Downstream raw materials:

Didesmethyldapoxetine

Dapoxetine hydrochloride

dapoxetine

N,N-dimethylamino-3-(naphthyl-1-oxy)-1-phenylprop-1-amine