6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: 6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE
• CAS No.: 30740-95-5
• Molecular Formula: C12H16ClNO4
• Molecular Weight: 273.71
• Hs Code.: 2933499090
• Mol file: 30740-95-5.mol

Synonyms:6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE

Chemical Property of 6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE

Chemical Property:

• PSA: 67.79000
• LogP: 1.93350

Purity/Quality:

98%min ^*data from raw suppliers

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,N,Xn
• Statements: 22-50
• Safety Statements: 61

MSDS Files:

Useful:

Technology Process of 6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE

There total 11 articles about 6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-amino-3-(3,4-dimethoxyphenyl)propanoic acid hydrochloride (115982-28-0) → (S)-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride (30740-95-5)

Guidance literature:

With hydrogenchloride; In water; 1) 3h, 90 deg C, 2) 0 deg C, 16h;

DOI:10.1055/s-1990-26936

Reference yield:

(Z)-2-phenyl-4-(3,4-dimethoxybenzylidene)-(4H)-1,3-oxazol-5-one (25349-37-5) → (S)-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride (30740-95-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / Na₂CO₃

2: 95 percent / H₂ / 10percent Pd-C / methanol / 72 h / 760 Torr

3: 93 percent / conc. HCl / H₂O / 20 h / Heating

4: 100 percent / conc. HCl / H₂O / 1) 3h, 90 deg C, 2) 0 deg C, 16h

With hydrogenchloride; hydrogen; palladium on activated charcoal; sodium carbonate; In methanol; water;

DOI:10.1055/s-1990-26936

Reference yield:

(Z)-2-phenyl-4-(3,4-dimethoxybenzylidene)-(4H)-1,3-oxazol-5-one (25349-37-5) → (R)-6,75,6-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride (30740-95-5,82586-62-7,130717-73-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / Na₂CO₃

2: H₂ / PF₆ / tetrahydrofuran / 17 h

3: 94.8 percent / conc. HCl / H₂O / 20 h / Heating

4: conc. HCl / H₂O / 1) 3h, 90 deg C, 2) 0 deg C, 16h

With hydrogenchloride; hydrogen; PF6; sodium carbonate; In tetrahydrofuran; water;

DOI:10.1055/s-1990-26936

upstream raw materials:

formaldehyd

2-amino-3-(3,4-dimethoxyphenyl)propanoic acid hydrochloride

(+/-)-methyl 2-benzoylamino-3-(3,4-dimethoxyphenyl)propanoate

(Z)-2-phenyl-4-(3,4-dimethoxybenzylidene)-(4H)-1,3-oxazol-5-one

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