2,6-DIMETHOXY-4-CHLOROPHENOL

Base Information

• Chemical Name: 2,6-DIMETHOXY-4-CHLOROPHENOL
• CAS No.: 108545-00-2
• Molecular Formula: C8H9ClO3
• Molecular Weight: 188.611
• Mol file: 108545-00-2.mol

Synonyms:2,6-DIMETHOXY-4-CHLOROPHENOL;4-Chloro-2,6-dimethoxyphenol

Chemical Property of 2,6-DIMETHOXY-4-CHLOROPHENOL

Chemical Property:

• PSA: 38.69000
• LogP: 2.06280

Purity/Quality:

98% ^*data from raw suppliers

2,6-DIMETHOXY-4-CHLOROPHENOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DIMETHOXY-4-CHLOROPHENOL

There total 4 articles about 2,6-DIMETHOXY-4-CHLOROPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2,3-trimethoxy-5-chlorobenzene (2675-80-1) → 4-chloro-2,6-dimethoxyphenol (108545-00-2)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 4h; regioselective reaction; Inert atmosphere;

DOI:10.1135/cccc2011017

Reference yield:

1,3-dimethoxy-2-hydroxy-benzene (91-10-1) → 4-chloro-2,6-dimethoxyphenol (108545-00-2)

Guidance literature:

With sodium hypochlorite; In methanol; at 10 ℃; for 0.333333h;

DOI:10.1016/0045-6535(94)90009-4

Reference yield:

1,3-dimethoxy-2-hydroxy-benzene (91-10-1) → 3-chloro-2,6-dimethoxyphenol (18113-22-9) + 4-chloro-2,6-dimethoxyphenol (108545-00-2)

Guidance literature:

With chlorine; In acetic acid; at 20 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1016/0045-6535(94)90009-4

upstream raw materials:

1,3-dimethoxy-2-hydroxy-benzene

1,2,3-trimethoxy-5-chlorobenzene

3,4,5-Trimethoxyaniline

Downstream raw materials:

N-{1-[(6-aminopyridin-2-yl)methyl]piperidin-4-yl}-2-{2-[(4-chloro-2,6-dimethoxyphenoxy)methyl]phenyl}-2-hydroxypropanamide

2-{2-[(4-chloro-2,6-dimethoxyphenoxy)methyl]phenyl}-2-hydroxypropanoic acid

2-{2-[(4-chloro-2,6-dimethoxyphenoxy)methyl]phenyl}propane-1,2-diol

5-chloro-1,3-dimethoxy-2-{[2-(1-methylethenyl)phenyl]methoxy}benzene

Refernces

• 1、 -. "NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF". Page/Page column 96. . Retrieved 2010/01/07.