2675-80-1Relevant academic research and scientific papers
NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF
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Page/Page column 95, (2010/01/07)
The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevent
Expeditious synthesis of bioactive allylphenol constituents of the genus Piper through a metal-free photoallylation procedure
Protti, Stefano,Fagnoni, Maurizio,Albini, Angelo
, p. 2868 - 2871 (2007/10/03)
Nine bioactive allylphenol (anisole) derivatives (e.g. eugenol, safrole and asaricin) present in several plants of the genus Piper have been synthesized in medium to high yield via aryl cation intermediates. This expeditious metal-free procedure involves the irradiation of the corresponding chlorophenols or chloroanisoles in a polar solvent (MeCN or, better, TFE or aqueous acetonitrile) in the presence of allyltrimethylsilane. Estragole has also been synthesized starting from the corresponding fluoroderivative and diazonium salt, though in a lower yield. The Royal Society of Chemistry 2005.
