3-Chloro-2,6-dimethoxyphenol

Base Information

• Chemical Name: 3-Chloro-2,6-dimethoxyphenol
• CAS No.: 18113-22-9
• Molecular Formula: C8H9ClO3
• Molecular Weight: 188.60800
• DSSTox Substance ID: DTXSID70551796
• Nikkaji Number: J569.090K
• Wikidata: Q82431647
• Mol file: 18113-22-9.mol

Synonyms:2,6-Dimethoxy-3-chlorophenol;3-Chloro-2,6-dimethoxyphenol;18113-22-9;Phenol, 3-chloro-2,6-dimethoxy-;chlorosyringol;DTXSID70551796

Chemical Property of 3-Chloro-2,6-dimethoxyphenol

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Boiling Point: 272.398oC at 760 mmHg
• Flash Point: 118.543oC
• PSA: 38.69000
• Density: 1.276g/cm3
• LogP: 2.06280
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 188.0240218
• Heavy Atom Count: 12
• Complexity: 142

Purity/Quality:

99.90% ^*data from raw suppliers

2,6-DIMETHOXY-3-CHLOROPHENOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=C(C=C1)Cl)OC)O

Technology Process of 3-Chloro-2,6-dimethoxyphenol

There total 9 articles about 3-Chloro-2,6-dimethoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dimethoxy-2-hydroxy-benzene (91-10-1) → 3-chloro-2,6-dimethoxyphenol (18113-22-9)

Guidance literature:

With carbon disulfide; chlorine;

Reference yield:

3-chlorosyringol acetate (155593-13-8) → 3-chloro-2,6-dimethoxyphenol (18113-22-9)

Guidance literature:

With sodium hydroxide; In methanol; at 40 ℃; for 1h;

DOI:10.1016/0045-6535(94)90009-4

Reference yield:

1,3-dimethoxy-2-hydroxy-benzene (91-10-1) → 3-chloro-2,6-dimethoxyphenol (18113-22-9) + 4-chloro-2,6-dimethoxyphenol (108545-00-2)

Guidance literature:

With chlorine; In acetic acid; at 20 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1016/0045-6535(94)90009-4

upstream raw materials:

N-chloro-succinimide

1,3-dimethoxy-2-hydroxy-benzene

3-chlorosyringol acetate

sulfuryl dichloride

Downstream raw materials:

3,4-dibromo-5-chloro-2,6-dimethoxy-phenol

1,2,3-trimethoxy-4-chlorobenzene

3-chloro-2,6-dimethoxyphenyl triflate

2-bromo-6-chloro-3,5-dimethoxy-[1,4]benzoquinone