Streptochlorin

Base Information

Chemical Name:Streptochlorin
CAS No.:120191-51-7
Molecular Formula:C11H7ClN2O
Molecular Weight:218.63908
Hs Code.:
Mol file:120191-51-7.mol

Synonyms:Streptochlorin;3-(4-Chloro-5-oxazolyl)-1H-indole;Antibiotic SF 2583A;SF 2583A

Suppliers and Price of Streptochlorin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Streptochlorin
250ug
$ 316.00

Cayman Chemical
Streptochlorin
1mg
$ 235.00

Cayman Chemical
Streptochlorin
5mg
$ 999.00

American Custom Chemicals Corporation
STREPTOCHLORIN 95.00%
5MG
$ 456.05

AK Scientific
Streptochlorin
1mg
$ 417.00

Adipogen Life Sciences
Streptochlorin ≥95%(HPLC)
1 mg
$ 240.00

Adipogen Life Sciences
Streptochlorin ≥95%(HPLC)
250 μg
$ 80.00

Total 9 raw suppliers

Chemical Property of Streptochlorin

Chemical Property:

PSA：41.82000
LogP:3.47630

Purity/Quality:

98%Min ^*data from raw suppliers

Streptochlorin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the production of reactive oxygen species (ROS) in, Hep3B human hepatocellular carcinoma cells. It does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 μM. Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-α and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB).
Uses Streptochlorin is an antineoplastic agent and a potential chemotherapeutic agent for treating cholangiocarcinoma.

Technology Process of Streptochlorin

There total 11 articles about Streptochlorin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 120191-50-6
5-(1H-indol-3-yl)oxazole

: 120191-51-7
streptochlorin

Guidance literature:: With N-chloro-succinimide; In tetrahydrofuran; tetrachloromethane; at 50 ℃; for 8h;
DOI:10.1016/j.ejmech.2012.04.012

Reference yield: 64.0%

: 1383483-14-4
4-chloro-5-(1-(phenylsulfonyl)-1H-indol-3-yl)oxazole

: 120191-51-7
streptochlorin

Guidance literature:: With water; sodium hydroxide; In ethanol; for 2h; Reflux;
DOI:10.1016/j.ejmech.2012.04.012

Reference yield: 56.0%

: 4-((2-methoxyphenyl)thio)-2-(triisopropylsilyl)-5-(1-(triisopropylsilyl)-1H-indol-3-yl)oxazole

: 120191-51-7
streptochlorin

Guidance literature:: 4-((2-methoxyphenyl)thio)-2-(triisopropylsilyl)-5-(1-(triisopropylsilyl)-1H-indol-3-yl)oxazole; With borane-THF; In tetrahydrofuran; at -78 ℃;

With n-butyllithium; hexachloroethane; In tetrahydrofuran; hexane; at -78 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; ethanol; hexane; water; for 16h;
DOI:10.1021/acs.orglett.1c00288